07-598
Anti-GluR2/3 Antibody
Upstate®, from rabbit
Sinónimos:
Anti-GluA2, Anti-GluR-2, Anti-GluR-B, Anti-GluR-K2, Anti-GluR2
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|
Acerca de este artículo
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, human, chicken, monkey, mouse
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... GRIA2(2891)
General description
Immunogen
Application
Neuroscience
Neurotransmitters & Receptors
Neurodegenerative Diseases
Biochem/physiol Actions
Physical form
Preparation Note
Analysis Note
Mouse brain tissue, rat brain microsomal preparation, human brain lysates
Legal Information
Disclaimer
1 of 1
Este artículo | |||
|---|---|---|---|
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| antibody form purified immunoglobulin | antibody form purified antibody | antibody form purified antibody | antibody form culture supernatant |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| clone polyclonal | clone polyclonal | clone monoclonal | clone C3T, monoclonal |
| species reactivity rat, human, chicken, monkey, mouse | species reactivity human, rat | species reactivity rat, mouse | species reactivity human, chimpanzee, rat, mouse |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
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Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenido relacionado
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 07-598 | 04053252335914 |