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Z101

Zimelidine dihydrochloride

solid

Sinónimos:

(Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine dihydrochloride

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C16H17BrN2 · 2HCl
Número CAS:
61129-30-4
Peso molecular:
390.15
NACRES:
NA.77
PubChem Substance ID:
24278138
UNSPSC Code:
12352200
MDL number:
MFCD00069358
Form:
solid
Para consultas sobre este producto Z101, póngase en contacto con su oficina o distribuidor locales de Merck. Póngase en contacto con el Servicio técnico
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form

solid

color

white

solubility

0.1 M HCl: 45 mg/mL, H2O: 66 mg/mL

originator

AstraZeneca

SMILES string

Cl[H].Cl[H].[H]\C(CN(C)C)=C(/c1ccc(Br)cc1)c2cccnc2

InChI

1S/C16H17BrN2.2ClH/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;/h3-10,12H,11H2,1-2H3;2*1H/b16-9-;;

InChI key

CXGURXWCQYHDIR-ULPVBNQHSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Application

Zimelidine dihydrochloride has been used as a serotonin transport inhibitor to study its inhibitory role in the uptake of exogenous serotonin by bipolar cells.[1]

Biochem/physiol Actions

Zimelidine, an antidepressant, is a specific 5-hydroxytryptamine (5-HT) reuptake inhibitor,[2] that can be used in treating phobic anxiety. It is very effective and can be tolerated well in elderly individuals. This serotonin transport inhibitor[1] is less likely than other antidepressants to have cardiovascular side effects. Unlike other tricyclic antidepressants, Zimelidine might promote weight loss but not weight gain.[3]

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold with the permission of Astra AB.

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Este artículo
SML2635SML0694U101
Zimelidine dihydrochloride solid

Sigma-Aldrich

Z101

Zimelidine dihydrochloride

Z944 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML2635

Z944 hydrochloride

BX-795 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0694

BX-795 hydrochloride

5-Methylurapidil solid

Sigma-Aldrich

U101

5-Methylurapidil

form

solid

form

powder

form

powder

form

solid

solubility

0.1 M HCl: 45 mg/mL, H2O: 66 mg/mL

solubility

H2O: 2 mg/mL, clear

solubility

DMSO: 15 mg/mL, clear

solubility

H2O: 0.4 mg/mL, 0.1 M HCl: 3.8 mg/mL

color

white

color

white to beige

color

white to light brown

color

white

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Gene Information

-

Gene Information

-

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

originator

AstraZeneca

originator

-

originator

-

originator

-

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
048K1486
107K1398
107K1054
067K1375
074K0804

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M G Frank et al.
Brain research, 768(1-2), 287-293 (1997-11-22)
Chronic postnatal exposure to clomipramine (CMI), a monoamine uptake inhibitor, results in persistent alterations in adult rat REM sleep. These effects have been ascribed to CMI's ability to block neonatal active sleep (AS). However, these effects have not been obtained
R W Fuller
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 45, 167-204 (1995-01-01)
Fluoxetine, zimelidine, sertraline, paroxetine, fluvoxamine, indalpine and citalopram are the selective inhibitors of serotonin uptake that have been most widely studied. Some of these compounds are or have been used clinically in the treatment of mental depression, obsessive-compulsive disorder and
Kanika Ghai et al.
Journal of neurochemistry, 111(1), 1-14 (2009-07-22)
The neurotransmitter serotonin is synthesized in the retina by one type of amacrine neuron but accumulates in bipolar neurons in many vertebrates. The mechanisms, functions and purpose underlying serotonin accumulation in bipolar cells remain unknown. Here, we demonstrate that exogenous
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Número de artículo de comercio global

SKUGTIN
Z101-100MG04061832086453
Z101-500MG04061832086460
Z101-25MG04061832094397

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