The concentration of bFGF in this product varies from lot to lot. This information can be provided by the Technical Service team. Please visit https://www.sigmaaldrich.com/techservice and click on "Product Technical Inquiries" under the Products Section with all the required information for further assistance.
F9786
Fibroblast Growth Factor-Basic Heparin Stabilized human
recombinant, expressed in E. coli, aqueous solution, suitable for cell culture
Sinónimos:
rhbFGF
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Acerca de este artículo
Biological source:
human
Recombinant:
expressed in E. coli
Form:
aqueous solution
Nombre del producto
Fibroblast Growth Factor-Basic Heparin Stabilized human, FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
sterility
sterile-filtered
form
aqueous solution
potency
0.03-3.0 ng/mL ED50/EC50
quality
endotoxin tested
packaging
pkg of 1 and 5 mL
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... FGF2(2247)
General description
Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.[1]
Application
Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV).[2] It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.[3]
Biochem/physiol Actions
Fibroblast growth factor 2 (FGF2) participates in tissue development and repair.[1] It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system.[4] FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor.[1] bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types.[4] In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion.[5] It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
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Este artículo | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant - | recombinant expressed in E. coli |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| biological source human | biological source human | biological source bovine pituitary glands | biological source human |
| form aqueous solution | form lyophilized powder | form lyophilized powder | form powder |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| packaging pkg of 1 and 5 mL | packaging pkg of 50 μg | packaging pkg of 1 μg | packaging pkg of 10 and 50 μg |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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