There's only the CoA for F8257. It's soluble at 50 mg/mL in CHCl3:MeOH (1:1) according to the CoA. Please consult the available literature for the use of solvents in in vitro testing.
F8257
Flunarizine dihydrochloride
≥98% (TLC), T-type Ca2+/Na+ channel blocker
Sinónimos:
1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
1 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 95,30 € |
10 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 452,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C26H26F2N2 · 2HCl
Número CAS:
Peso molecular:
477.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-216-6
MDL number:
Beilstein/REAXYS Number:
4284243
Assay:
≥98% (TLC)
95,30 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleNombre del producto
Flunarizine dihydrochloride, ≥98% (TLC)
Quality Segment
assay
≥98% (TLC)
originator
Johnson & Johnson
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
InChI
1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChI key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
General description
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Application
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Biochem/physiol Actions
Blocks T-type Ca2+/Na+ channels.
Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Este artículo | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay - | assay - | assay ≥98% (TLC) |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| originator Johnson & Johnson | originator - | originator - | originator - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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For in vitro testing, in what solvent can it be dissolved? DMSO or other. Also, we require product datasheet which is not available on the website
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