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E4632

Econazole nitrate salt

Sinónimos:

1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C18H15Cl3N2O · HNO3
Número CAS:
24169-02-6
Peso molecular:
444.70
NACRES:
NA.85
PubChem Substance ID:
24894567
UNSPSC Code:
51102829
EC Number:
246-053-5
MDL number:
MFCD00058160

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form

powder or crystals

Quality Level

200

color

white to off-white

antibiotic activity spectrum

Gram-positive bacteria, fungi

mode of action

cell membrane | interferes, cell wall synthesis | interferes, enzyme | inhibits

SMILES string

O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1

InChI

1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)

InChI key

DDXORDQKGIZAME-UHFFFAOYSA-N

General description

Chemical structure: imidazole

Application

Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes.

Biochem/physiol Actions

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

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Este artículo
M3512K1003C6019
Econazole nitrate salt

Sigma-Aldrich

E4632

Econazole nitrate salt

(±)-Miconazole nitrate salt imidazole antibiotic

Sigma-Aldrich

M3512

(±)-Miconazole nitrate salt

Ketoconazole 99.0-101.0% (EP, titration), meets EP testing specifications

Sigma-Aldrich

K1003

Ketoconazole

Clotrimazole

Sigma-Aldrich

C6019

Clotrimazole

mode of action

cell membrane | interferes, enzyme | inhibits, cell wall synthesis | interferes

mode of action

enzyme | inhibits

mode of action

enzyme | inhibits

mode of action

cell membrane | interferes, protein synthesis | interferes

antibiotic activity spectrum

Gram-positive bacteria, fungi

antibiotic activity spectrum

fungi, mycobacteria

antibiotic activity spectrum

Gram-positive bacteria, fungi, yeast

antibiotic activity spectrum

fungi

form

powder or crystals

form

-

form

powder

form

powder

color

white to off-white

color

white to off-white

color

white to off-white

color

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000539586
0000539587
0000539587
0000539586
0000488019

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Contenido relacionado

Product Information Sheet - E4632

Product Information Sheet

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PloS one, 13(1), e0190931-e0190931 (2018-01-06)
Lactobacillus plantarum strains PM411 and TC92 can efficiently control bacterial plant diseases, but their fitness on the plant surface is limited under unfavourable low relative humidity (RH) conditions. To increase tolerance of these strains to water stress, an adaptive strategy
Núria Daranas et al.
Applied and environmental microbiology, 84(10) (2018-03-11)
A viability quantitative PCR (v-qPCR) assay was developed for the unambiguous detection and quantification of Lactobacillus plantarum PM411 viable cells in aerial plant surfaces. A 972-bp region of a PM411 predicted prophage with mosaic architecture enabled the identification of a
C J Jackson et al.
FEMS microbiology letters, 192(2), 159-162 (2000-11-07)
Azole antifungals are central to therapy and act by inhibiting a cytochrome P450, sterol 14-demethylase and blocking normal sterol synthesis. Our recent identification of a mycobacterial sterol biosynthetic pathway led us to probe the efficacy of a range of these
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Número de artículo de comercio global

SKUGTIN
E4632-5G04061833603895
E4632-100G04061833603871
E4632-25G04061833603888

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