C6019 is supplied in powder form. It is soluble in Chloroform at 50.0 - 52.0 mg/ml. But the information on the absorption molecular coefficient of clotrimazole is currently unavailable. However, I conducted an extensive literature search and found some relevant information. Clotrimazole showed absorption maxima (λ max) at 263 nm, and linearity was obtained by concentration versus absorbance for clotrimazole with a correlation coefficient of r = 0.999.
C6019
Clotrimazole
98.5-100.5% (dry basis), powder, Ca²⁺-activated K⁺ channels inhibitor
Sinónimos:
1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
5 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 141,00 € |
25 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 370,00 € |
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C22H17ClN2
Número CAS:
Peso molecular:
344.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-764-8
MDL number:
Form:
powder
141,00 €
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Servicio técnico
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Permítanos ayudarleNombre del producto
Clotrimazole,
form
powder
Quality Segment
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes, protein synthesis | interferes
originator
Schering Plough
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
InChI
1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChI key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
Gene Information
human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)
General description
Chemical structure: imidazole
Application
Clotrimazole has been used:
- to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, in Candida species, upon treatment with azole antibioticsPMID 10991846
- to study the development of resistance in Candida species isolated from patients undergoing prolonged antifungal treatmentPMID 1804002
- to induce stress granules via mitochondrial stressPMID 15967811PMID 22563080
- for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB)PMID 10467272
- to inhibit cytochrome P450 enzyme in cell culturesPMID 17085635
Biochem/physiol Actions
Clotrimazole is a specific inhibitor of Ca2+-activated K+ channels.PMID 11732639 It is an antifungal azole. Clotrimazole is a derivative of imidazole and has similar antimicrobial action and activity to ketoconazole.PMID 12368427 It inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Este artículo | |||
|---|---|---|---|
| description - | description Pharmaceutical Secondary Standard; Certified Reference Material | description European Pharmacopoeia (EP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard |
| form powder | form - | form - | form solid |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| originator Schering Plough | originator - | originator - | originator - |
| antibiotic activity spectrum fungi | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action cell membrane | interferes, protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| Gene Information human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576) | Gene Information - | Gene Information - | Gene Information - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Please provide the absorption molecular coefficient of clotrimazole and the solvent used to quantify my clotrimazole solutions.
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