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Merck

A3773

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

≥99%

Sinónimos:

THA hydrochloride hydrate, Tacrine hydrochloride, Tetrahydroaminacrine hydrochloride hydrate

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Fórmula empírica (notación de Hill):
C13H14N2 · HCl · xH2O
Número CAS:
206658-92-6
Peso molecular:
234.72 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24278139
UNSPSC Code:
51111800
MDL number:
MFCD00150067
Assay:
≥99%
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥99%

form

powder

mp

284-286 °C (lit.)

solubility

H2O: soluble

SMILES string

O.Cl.Nc1c2CCCCc2nc3ccccc13

InChI

1S/C13H14N2.ClH.H2O/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H;1H2

InChI key

PXGRMZYJAOQPNZ-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

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Este artículo
A7410H4413A79922
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate ≥99%

Sigma-Aldrich

A3773

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

Amiloride hydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

A7410

Amiloride hydrochloride hydrate

Hydroxyfasudil hydrochloride hydrate ≥98% (HPLC), solid

Sigma-Aldrich

H4413

Hydroxyfasudil hydrochloride hydrate

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate ≥99%

Sigma-Aldrich

A79922

9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

form

powder

form

powder

form

solid

form

solid

assay

≥99%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99%

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

solubility

H2O: soluble

solubility

H2O: 50 mg/mL, clear, yellow-green

solubility

H2O: >5 mg/mL

solubility

-

mp

284-286 °C (lit.)

mp

285-288 °C (dec.)

mp

-

mp

284-286 °C (lit.)

Gene Information

human ... ACHE(43)

Gene Information

human ... ABP1(26), ACCN1(40), ACCN2(41), PLAU(5328), SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), TNF(7124)
mouse ... Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544)
rat ... Abp1(65029), Accn1(25364), Accn2(79123), Plau(25619), Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782)

Gene Information

-

Gene Information

-

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
0000257141
0000234461
0000223246
0000223246
0000234461

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M Harel et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(19), 9031-9035 (1993-10-01)
Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes with ligands were determined at 2.8-A resolution. In a complex with edrophonium, and quaternary nitrogen of the ligand
Go Koganemaru et al.
Pharmacology, biochemistry, and behavior, 126, 103-108 (2014-09-30)
We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats. Rats received intraperitoneal injection of cabergoline (0.5, 1.0, or 5.0mg/kg), rotigotine (1.0, 2.5, or 10.0mg/kg), or vehicle 30min before intraperitoneal injection
Dietrich E Lorke et al.
Molecules (Basel, Switzerland), 25(7) (2020-04-02)
Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory. Experimental data indicate that superior therapeutic results can be obtained when reversible cholinesterase inhibitors are administered before
Satish N Dighe et al.
ACS omega, 5(48), 30971-30979 (2020-12-17)
Cholinesterases (ChE) are well-known drug targets for the treatment of Alzheimer's disease (AD). In continuation of work to develop novel cholinesterase inhibitors, we utilized a structure-based scaffold repurposing approach and discovered six novel ChE inhibitors from our recently developed DNA
Jinggong Liu et al.
Biochimica et biophysica acta, 1840(9), 2886-2903 (2014-05-14)
Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that is characterized by dementia, cognitive impairment, and memory loss. Diverse factors are related to the development of AD, such as increased level of β-amyloid (Aβ), acetylcholine, metal ion deregulation, hyperphosphorylated
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SKUGTIN
A3773-10G04061832945248
A3773-1G04061833367889
A3773-5G04061832945255

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