360512

Glycocholic Acid, Sodium Salt

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

• Sinónimos: Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate
• Número CAS: 863-57-0
• MDL number: MFCD00669624
• UNSPSC Code: 12352106
• NACRES: NA.21
• Assay: 100.1% dry basis (titration)
• Form: solid
• Storage condition: OK to freeze

Propiedades

• Quality Segment: 100
• description: Merck USA index - 14, 4494
• assay: 100.1% dry basis (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• aggregation number: 2.1
• color: white to off-white
• pKa: 3.8
• CMC: 7.1 mM
• solubility: water: 200 mg/mL, ethanol: soluble
• shipped in: ambient
• storage temp.: 15-25°C
• SMILES string: [Na+].N(CC(=O)[O-])C(=O)CCC(C1C2(C(C3C(C4(C(CC3O)CC(CC4)O)C)CC2O)CC1)C)C
• InChI: 1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
• InChI key: OABYVIYXWMZFFJ-UHFFFAOYSA-M

Descripción

General description

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes.[1] Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.[2]Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pK_a: 3.8).

Application

Glycocholic Acid, Sodium Salt- is suitable for use:

• as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples[3]
• in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K[4]
• to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K₁) to analyze its influence on the quality and stability of the mixed micelle systems[2]

Biochem/physiol Actions

Glycocholic acid (GCA) is involved in the emulsification of fats.[1] Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).[1]

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable