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I6284

Anti-Human IgE (ε-chain specific) antibody produced in goat

Name: Anti-Human IgE (ε-chain specific) antibody produced in goat
Brand: SIGMA
Price: 428 CHF

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti Human Ige, Anti-Human IgE - Anti-Human IgE (ε-chain specific) antibody produced in goat, Anti-Human Ige

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Conditionnement	Référence	Disponibilité	Prix
1 mg		Vérifier la disponibilité des articles du panier	428.00 CHF

A propos de cet article

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD00162427

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ODD

Citations:

428.00 CHF

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Propriétés

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

Ouchterlony double diffusion: suitable

storage temp.

2-8°C

target post-translational modification

unmodified

Description

General description

IgE is a class of immunoglobulins that is produced only in mammals. IgE is secreted by mast cells in response to allergens and is important in immunity against parasites. It also is the most important factor in the pathophysiology of anaphylaxis or type I hypersensitivity. The antibody preparation is specific for human IgE when tested against purified human IgA, IgG, IgM, Bence Jones κ, and Bence Jones λ proteins. Identity and purity of the antibody is established by immunoelectrophoresis.

Immunogen

Purified human IgE (myeloma)

Application

Anti-Human IgE (epsilon-chain specific) antibody may be used as a control in various immunoassays.

Physical form

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2.

Preparation Note

Reconstitute with 0.135 M sodium chloride to achieve a 1 mg/mL solution of antibody.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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1 of 1

Cet article	I0884	A3525	I2136
Sigma-Aldrich I6284 Anti-Human IgE (ε-chain specific) antibody produced in goat	Sigma-Aldrich I0884 Anti-Human IgA (α-chain specific) antibody produced in goat	Sigma-Aldrich A3525 Anti-Human IgE (ε-chain specific)−Alkaline Phosphatase antibody produced in goat	Sigma-Aldrich I2136 Anti-Human IgG (Fc specific) antibody produced in goat
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source goat	biological source goat	biological source goat	biological source goat
conjugate unconjugated	conjugate unconjugated	conjugate alkaline phosphatase conjugate	conjugate unconjugated
technique(s) Ouchterlony double diffusion: suitable	technique(s) Ouchterlony double diffusion: suitable	technique(s) direct ELISA: 1:7,000-1:21,000	technique(s) indirect ELISA: 1:10,000
species reactivity human	species reactivity -	species reactivity human	species reactivity -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C

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Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

0000471418

SLCR4886

0000309287

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Contenu apparenté

Data Sheet - I6284

Instructions

IgE and mast cells in allergic disease.

Stephen J Galli et al.

Nature medicine, 18(5), 693-704 (2012-05-09)

Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts. However, a large body of evidence

The pseudoallergen receptor MRGPRX2 on peripheral blood basophils and eosinophils: Expression and function.

Bettina Wedi et al.

Allergy, 75(9), 2229-2242 (2020-02-01)

Mas-related G protein-coupled receptor X2 (MRGPRX2) is regarded as a mast cell-specific receptor mediating non-IgE-dependent activation. We aimed to investigate whether human basophils and eosinophils express functional MRGPRX2. Flow cytometry, immunocytochemistry, immunofluorescence, Western blot, and RT-PCR were performed in highly

CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.

Shiteng Duan et al.

The Journal of clinical investigation, 129(3), 1387-1401 (2019-01-16)

Allergen immunotherapy for patients with allergies begins with weekly escalating doses of allergen under medical supervision to monitor and treat IgE mast cell-mediated anaphylaxis. There is currently no treatment to safely desensitize mast cells to enable robust allergen immunotherapy with

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Numéro d'article de commerce international

Référence	GTIN
I6284-1MG	04061826703373

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