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D034

(−)-Butaclamol hydrochloride

Name: (−)-Butaclamol hydrochloride
Brand: SIGMA

solid

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₅H₃₁NO · HCl

Numéro CAS:

55528-08-0

Poids moléculaire :

397.98

NACRES:

NA.77

PubChem Substance ID:

24893227

UNSPSC Code:

12352200

MDL number:

MFCD00082308

Form:

solid

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Propriétés

form

solid

optical activity

[α]27/D −222° in methanol(lit.)

color

white

solubility

H₂O: 0.25 mg/mL, ethanol: 1 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.4 mg/mL, alcohol-water mixtures: soluble (Dissolve solid in alcohol and dilute with water.)

SMILES string

Cl[H].[H][C@]12C[C@](O)(CCN1C[C@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C

InChI

1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m1./s1

InChI key

QZRUMKUMFJJARD-OMMJFLKZSA-N

Description

Biochem/physiol Actions

Dopamine receptor antagonist; less active enantiomer.

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Cet article	O111	R101	C141
Sigma-Aldrich D034 (−)-Butaclamol hydrochloride	Sigma-Aldrich O111 Octoclothepin maleate salt	Sigma-Aldrich R101 Ranitidine hydrochloride	Sigma-Aldrich C141 CGS-21680 hydrochloride hydrate
form solid	form solid	form solid	form solid
solubility H₂O: 0.25 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.4 mg/mL, alcohol-water mixtures: soluble (Dissolve solid in alcohol and dilute with water.), ethanol: 1 mg/mL	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >21 mg/mL	solubility H₂O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL	solubility DMSO: >10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL
color white	color white	color tan	color white
optical activity [α]27/D −222° in methanol(lit.)	optical activity -	optical activity -	optical activity -

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effect of structural analogs of butaclamol (a new antipsychotic drug) on striatal homovanillic acid and adenyl cyclase of olfactory tubercle in rats.

T A Pugsley et al.

Canadian journal of physiology and pharmacology, 54(4), 510-515 (1976-08-01)

The 3-isopropyl (I), 3-cyclohexyl (II) and 3-phenyl (III) analogs of the new antipsychotic drug butaclamol, which contains a 3-tertiary butyl group, and their respective (+)-enantiomers, but not (-)-enantiomers, caused a dose related elevation of rat striatal homovanillic acid concentration, indicative

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Numéro d'article de commerce international

Référence	GTIN
D034-25MG	04061832090030

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Principaux documents

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(−)-Butaclamol hydrochloride

solid

A propos de cet article

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