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64367

L-Methionine 7-amido-4-methylcoumarin trifluoroacetate salt

Name: <SC>L</SC>-Methionine 7-amido-4-methylcoumarin trifluoroacetate salt
Brand: SIGMA

≥99.0% (sum of enantiomers, HPLC)

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₅H₁₈N₂O₃S · C₂HF₃O₂

Numéro CAS:

94367-35-8

Poids moléculaire :

420.40

NACRES:

NA.32

PubChem Substance ID:

57651980

UNSPSC Code:

12352209

MDL number:

MFCD00210065

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Propriétés

Quality Level

100

assay

≥99.0% (sum of enantiomers, HPLC)

optical activity

[α]20/D +68±3°, c = 1% in methanol

storage temp.

2-8°C

SMILES string

OC(=O)C(F)(F)F.CSCC[C@H](N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C15H18N2O3S.C2HF3O2/c1-9-7-14(18)20-13-8-10(3-4-11(9)13)17-15(19)12(16)5-6-21-2;3-2(4,5)1(6)7/h3-4,7-8,12H,5-6,16H2,1-2H3,(H,17,19);(H,6,7)/t12-;/m0./s1

InChI key

VSAUWUJWXBUSEU-YDALLXLXSA-N

Description

Application

L-Methionine 7-amido-4-methylcoumarin trifluoroacetate and its analogues may be used to study the kinetics of methionine aminopeptidase (hMetAP2). L-Methionine 7-amido-4-methylcoumarin trifluoroacetate may be use with other substrates to assess the specificity of various aminopeptidases.

Other Notes

Substrate for calpain[1]

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Cet article	05511	A4302	B7313
Sigma-Aldrich 64367 L-Methionine 7-amido-4-methylcoumarin trifluoroacetate salt	Sigma-Aldrich 05511 N-Acetyl-Arg-Gly-Lys(acetyl)-7-amido-4-methylcoumarin trifluoroacetate salt	Sigma-Aldrich A4302 L-Alanine 7-amido-4-methylcoumarin trifluoroacetate salt	Sigma-Aldrich B7313 L-BNP trifluoroacetate salt
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
assay ≥99.0% (sum of enantiomers, HPLC)	assay ≥98% (HPLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)
optical activity [α]20/D +68±3°, c = 1% in methanol	optical activity -	optical activity -	optical activity -

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs.

Gabriel Rinaldi et al.

Molecular and biochemical parasitology, 167(2), 118-126 (2009-05-26)

Schistosoma mansoni leucine aminopeptidase (LAP) is thought to play a central role in hatching of the miracidium from the schistosome egg. We identified two discrete LAPs genes in the S. mansoni genome, and their orthologs in S. japonicum. The similarities

Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates.

T Sasaki et al.

The Journal of biological chemistry, 259(20), 12489-12494 (1984-10-25)

Homogeneous porcine calpain (Ca2+-dependent cysteine proteinase) was found to hydrolyze a variety of peptides and synthetic substrates. Leu-Trp-Met-Arg-Phe-Ala, eledoisin-related peptide, alpha-neoendorphin, angiotensin I, luteinizing hormone-releasing hormone, neurotensin, dynorphin, glucagon, and oxidized insulin B chain were cleaved with a general preference

Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2).

G Yang et al.

Biochemistry, 40(35), 10645-10654 (2001-08-29)

The steady-state kinetics of a full-length and truncated form of the type 2 human methionine aminopeptidase (hMetAP2) were analyzed by continuous monitoring of the amide bond cleavage of various peptide substrates and methionyl analogues of 7-amido-4-methylcoumarin (AMC) and p-nitroaniline (pNA)

Numéro d'article de commerce international

Référence	GTIN
282650-500MG	04061826228425
282650-1G	04061826671443
64367-25MG	04061833277768

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Principaux documents

Passer à

L-Methionine 7-amido-4-methylcoumarin trifluoroacetate salt

≥99.0% (sum of enantiomers, HPLC)

A propos de cet article

Quality Level

assay

optical activity

storage temp.

SMILES string

InChI

InChI key

Application

Other Notes

Comparer avec des articles similaires

Cet article

Informations sur la sécurité

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

Classe de stockage

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificats d'analyse (COA)

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Numéro d'article de commerce international

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