ABC342

Anti-KPNA2 Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Karyopherin alpha nucleoprotein interactor 2, Importin alpha2, IPOA1, RAG cohort protein 1, QIP2, Karyopherin subunit alpha-2, SRP1-alpha
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: rat, human
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès UniProt: P52292
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... KPNA2(3838)

Description

Description générale

Karyopherin alpha nucleoprotein interactor 2 (KPNA2), also known as Importin alpha-2, RAG cohort protein 1 (RCH1), SRP1-alpha QIP2 (SRP1), is the alpha subunit 2 of karyopherin which functions as a cargo carrier that transports various complexes from cytoplasm into nucleus and forms a complex with importin subunit beta-1 and. KPNA2 is expressed ubiquitously and contains one IBB/importin beta domain, ten Armadillo repeats and three intervening nuclear localization sequences (NLSs). Recent studies have shown that KPNA2 plays an important role in tumorigenesis and tumor progression. KPNA2 is a heterodimer with KPNB1. It has been implied to interact with HIV-1 Vpr, PLAG1, ANP32E, ARL4A, CTNNBL1, NBN and APEX1 (via N-terminus). KPNA2 is also a component of a complex containing CSE1L, RAN and KPNA2 and interacts directly with CSE1L.

Immunogène

KLH-conjugated linear peptide corresponding to human KPNA2.

Application

Detect Importin using this rabbit polyclonal antibody, Anti-KPNA2 Antibody validated for use in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected KPNA2 in human heart tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Qualité

Evaluated by Western Blotting in rat heart tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected KPNA2 in 15 µg of rat heart tissue lysate.

Description de la cible

~55 kDa observed. Uncharacterized bands may appear in some lysate(s).

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Rat heart tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable