T5391
Apo-transferrina human
γ-irradiated, powder, BioXtra, suitable for cell culture, ≥98%
Sinónimos:
Siderofilina, Transferrina humana
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About This Item
Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.75
Productos recomendados
Nivel de calidad
esterilidad
γ-irradiated
Línea del producto
BioXtra
Análisis
≥98%
formulario
powder
mol peso
76-81 kDa
concentración
~25 mM
técnicas
cell culture | mammalian: suitable
impurezas
HIV and HBsAg, source material tested negative
iron, essentially free
solubilidad
H2O: 50 mg/mL
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... TF(7018)
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Descripción general
apo-Transferrin (aTF) human can be supplemented with iron or used to bind free iron present in media. It can be used to transport iron into mammalian cells.
Aplicación
apo-Transferrin human has been used as a supplement:
- in Dulbecco′s modified Eagle medium/HamF12 (DMEM/F-12) to culture human adrenocortical carcinoma cells
- in DMEM/F-12 to culture neural precursor cells from mice
- in collecting medium NCSU23 to culture preantral follicles from porcine ovaries
Acciones bioquímicas o fisiológicas
apo-Transferrin (aTF) is an endogenous iron chelator and shows protective effects in the host by scavenging free iron and preventing the formation of toxic reactive oxygen species (ROS). It shows a therapeutic effect against thalassemia. After the release of iron, receptor-bound apo-transferrin reaches the cell surface instead of being transported to lysosomes for degradation. The cell surface has a neutral pH that promotes the release of apo-transferrin from its receptor, where it can again circulate and bind additional iron to undergo further rounds of iron delivery to cells.
Otras notas
Proteína transportadora de hierro no hemo.
Cláusula de descargo de responsabilidad
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Artículos
Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.
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