SML3933
CLC-2 channel inhibitor, AK-42
≥98% (HPLC)
Sinónimos:
2-[[2,6-Dichloro-3-(phenylmethoxy)phenyl]amino]-3-pyridinecarboxylic acid, AK-42
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C19H14Cl2N2O3
Número CAS:
Peso molecular:
389.23
UNSPSC Code:
12352200
NACRES:
NA.21
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Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=C(NC2=C(Cl)C=CC(OCC3=CC=CC=C3)=C2Cl)N=CC=C1)O
InChI
1S/C19H14Cl2N2O3/c20-14-8-9-15(26-11-12-5-2-1-3-6-12)16(21)17(14)23-18-13(19(24)25)7-4-10-22-18/h1-10H,11H2,(H,22,23)(H,24,25)
InChI key
AYGDOYFDJDUPSS-UHFFFAOYSA-N
Biochem/physiol Actions
Specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly.
CLC-2 channel inhibitor AK-42 is a specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly. AK-42 causes selective and reversible blocking of CLC-2 currents.
CLC-2 channel inhibitor AK-42 is a specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly. AK-42 causes selective and reversible blocking of CLC-2 currents.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nature Communications, 14(1), 3424-3424 (2023)
Apurva A Oak et al.
Molecular pharmacology, 102(2), 106-115 (2022-06-10)
Loss of prosecretory Cl- channel CFTR activity is considered as the key cause of gastrointestinal disorders in cystic fibrosis including constipation and meconium ileus. Clc-2 is proposed as an alternative Cl- channel in intestinal epithelia that can compensate for CFTR
Anna K Koster et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(51), 32711-32721 (2020-12-06)
CLC-2 is a voltage-gated chloride channel that is widely expressed in mammalian tissues. In the central nervous system, CLC-2 appears in neurons and glia. Studies to define how this channel contributes to normal and pathophysiological function in the central nervous
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| SML3933-25MG | 04065271870550 |
| SML3933-5MG | 04065271870567 |