SML1891

PK11007

≥98% (HPLC)

• Sinónimos: 5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid
• Fórmula empírica (notación de Hill): C₆H₅ClN₂O₄S
• Número CAS: 38275-34-2
• Peso molecular: 236.63
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00507244
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(C)c1nc(c(cn1)Cl)C(=O)O
• InChI: 1S/C6H5ClN2O4S/c1-14(12,13)6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
• InChI key: WZUPWJVRWIVWEF-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding.

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable