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Merck

S1764

Complement sera human

lyophilized powder

Sinónimos:

Human Serum Complement

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UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
Biological source:
human
Origin:
USA origin
Form:
lyophilized powder
Shipped in:
dry ice

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biological source

human

Quality Level

form

lyophilized powder

origin

USA origin

technique(s)

cell culture | mammalian: suitable

impurities

virus, tested

shipped in

dry ice

storage temp.

−20°C

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1 of 4

Este artículo
S3269P2918S7764
biological source

human

biological source

mouse

biological source

human

biological source

rabbit

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | embryo: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | embryo: suitable, cell culture | mammalian: suitable

form

lyophilized powder

form

lyophilized powder

form

-

form

lyophilized powder

origin

USA origin

origin

-

origin

USA origin

origin

-

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

impurities

virus, tested

impurities

-

impurities

(mycoplasma tested, virus tested), ≤10 EU/mL endotoxin

impurities

-

General description

Complement serum is prepared from pooled human plasma and lyophilized from the amount of serum indicated on the label.

Application

Complement sera human has been used:
  • to incubate DLD-1 or SW-620 cells to quantify C5a release
  • in multiplex bead antibody-binding assay to assay C3d
  • in complement-dependent cytotoxicity assay

Complement sera human has been used:
  • to incubate DLD-1 or SW-620 cells to quantify C5a release[1]
  • in multiplex bead antibody-binding assay to assay C3d[2]
  • in complement-dependent cytotoxicity assay[3]

The activity of complement sera can be determined by hemolytic assays in vitro. [4]

Physical form

Lyophilized powder from indicated amount of serum

Analysis Note

Hemolytic titer (CH50 units per ml) is determined by method of Kabat and Mayer. Actual titer given on label.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Helen Kotanides et al.
Cancer immunology research, 8(10), 1300-1310 (2020-09-03)
The programmed cell death protein 1 receptor (PD-1) and programmed death ligand 1 (PD-L1) coinhibitory pathway suppresses T-cell-mediated immunity. We hypothesized that cotargeting of PD-1 and PD-L1 with a bispecific antibody molecule could provide an alternative therapeutic approach, with enhanced
Lisa Tomasi et al.
Open forum infectious diseases, 9(11), ofac554-ofac554 (2022-12-06)
The basis of the less severe clinical presentation of coronavirus disease 2019 (COVID-19) in children as compared with adults remains incompletely understood. Studies have suggested that a more potent boosting of immunity to endemic common cold coronaviruses (HCoVs) may protect
Savannah E Butler et al.
Frontiers in immunology, 11, 618685-618685 (2021-02-16)
Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role in the development of vaccines and antibody-based interventions. We report systemic and mucosal antibody responses in convalescent individuals who experienced varying severity of disease. Whereas assessment of neutralization
Yui Suzuki et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(14), 4388-4399 (2019-04-26)
The anti-CCR4 mAb, mogamulizumab, offers therapeutic benefit to patients with adult T-cell leukemia-lymphoma (ATL), but skin-related adverse events (AE) such as erythema multiforme occur frequently. The purpose of this study was to determine the mechanisms by which mogamulizumab causes skin-related
Chiaki Kawabata et al.
Biological & pharmaceutical bulletin, 44(2), 219-224 (2021-02-02)
Baculovirus vectors (BVs) are safely able to transduce foreign genes and express them in mammalian cells. However, the transduction activity of BVs is strongly reduced by the attack of serum complement, which is one of the major obstacles in the

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SKUGTIN
S1764-1ML04061836913861
S1764-5X1ML04061836913960

Preguntas

  1. Hello. This product is a pool of how many donnors ? Thanks for your help

    1 respuesta
    1. The donor pool size varies from lot to lot. Historical data indicates that the raw material is typically derived from a pool of 12 - 15 donors.

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