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S1563

SKF-86466 hydrochloride

Name: SKF-86466 hydrochloride
Brand: SIGMA

solid, ≥98% (HPLC)

Sinónimos:

6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride

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Fórmula lineal:

C₁₁H₁₄ClN·HCl

Número CAS:

86129-54-6

Peso molecular:

232.15

UNSPSC Code:

12352200

PubChem Substance ID:

24278695

MDL number:

MFCD03453012

Assay:

≥98% (HPLC)

Form:

solid

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Propiedades

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: 24 mg/mL

SMILES string

Cl.CN1CCc2cccc(Cl)c2CC1

InChI

1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H

InChI key

JKQKVNMNAIFCFS-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Descripción

Application

SKF 86466 was used to study adrenoceptor signaling in rat limbic seizure models.[1][2]

Biochem/physiol Actions

SKF 86466 binds specifically to α2-adrenoceptors at pre- and post-junctional sites but was also reported to antagonize α1-aderenoceptors in humans.[3] The structural similarity of receptors enables SKF 86466 binding to 5-HT1A receptors.[4]

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

100K47141

100K4714

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Post-hypoxic frequency decline does not depend on alpha2-adrenergic receptors in the adult rat.

S K Coles et al.

Brain research, 794(2), 267-273 (1998-06-12)

The aim of this study was to determine whether post-hypoxic frequency decline (PHFD) requires central activation of alpha2-adrenergic receptors. PHFD is defined as the undershoot in respiratory frequency that occurs immediately following brief hypoxic periods. Adult anesthetized, vagotomized rats were

alpha-1 and alpha-2 Adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury.

A H Hord et al.

Anesthesia and analgesia, 92(6), 1558-1562 (2001-05-29)

Phentolamine, a nonspecific alpha 1- and alpha 2-adrenergic antagonist, relieves pain in patients with reflex sympathetic dystrophy. We sought to determine whether phentolamine, prazosin (alpha 1 antagonist), or SKF86466 (alpha 2 antagonist) relieve thermal hyperalgesia in rats with neuropathic pain.

Differential cardiorespiratory control elicited by activation of ventral medullary sites in mice.

F P Tolentino-Silva et al.

Journal of applied physiology (Bethesda, Md. : 1985), 89(2), 437-444 (2000-08-05)

We studied the respiratory and blood pressure responses to chemical stimulation of two regions of the ventral brainstem in mice: the rostral and caudal ventrolateral medulla (RVLM and CVLM, respectively). Stimulation of the RVLM by microinjections of the excitatory amino