The purity of this material is not determined. The concentration of Protein A and Biotin are reported individually in the Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
https://www.sigmaaldrich.com/product/sigma/p2165#product-documentation
P2165
Protein A–Biotin from Staphylococcus aureus
lyophilized powder
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2 MG
257,00 €
257,00 €
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2 MG
257,00 €
About This Item
257,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel
Productos recomendados
conjugado
biotin conjugate
Nivel de calidad
Formulario
lyophilized powder
composición
Protein, ≥70% biuret
Extensión del etiquetado
3.0-8.0 mol biotin per mol Protein A
temp. de almacenamiento
2-8°C
Descripción general
Protein A (SpA) is a 42kDa virulence factor produced by Staphylococcus aureus, and is composed of five highly homologous consecutive extracellular Ig-binding domains, namely domains E, D, A, B, and C. This protein is present in both secreted and membrane-associated forms.[1]
Especificidad
Binds IgG only from most mammals, except rat, goat, and sheep
Acciones bioquímicas o fisiológicas
Protein A (SpA) causes B cells death in vitro, by binding to the Fc region of antibody and the Fab regions of the B-cell receptor, thus inhibiting its opsonophagocytosis. This protein is thought to be implicated in the evasion of host immune responses by Staphylococcus aureus, and thus, might be a candidate for vaccine development approaches to prevent severe S. aureus infections.[2] S. aureus is responsible for nosocomial infections as well as a variety of human infections, such as food poisoning, toxic shock syndrome, endocarditis, septicemia, skin infections, soft tissue infections, and bone infections. It is also responsible for bovine and ovine mastitis. SpA typing or DNA sequence analysis of the variable repeat region of protein A gene is useful in determining S. aureus outbreak strains from those strains that are epidemiologically insignificant.[3]
Forma física
Lyophilized powder containing sodium citrate
Nota de preparación
Prepared from P 6031, coupled to biotin by an amide bond through an aminocaproyl spacer.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Proceedings of the National Academy of Sciences of the United States of America, 97(10), 5399-5404 (2000-05-11)
Staphylococcus aureus produces a virulence factor, protein A (SpA), that contains five homologous Ig-binding domains. The interactions of SpA with the Fab region of membrane-anchored Igs can stimulate a large fraction of B cells, contributing to lymphocyte clonal selection. To
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New, as yet undiscovered aptamers for Protein A were identified by applying next generation sequencing (NGS) to a previously selected aptamer pool. This pool was obtained in a classical SELEX (Systematic Evolution of Ligands by EXponential enrichment) experiment using the
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