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P0778

Pindolol

Name: Pindolol
Brand: SIGMA
Price: 69.6 EUR

≥98% (TLC), β1-adrenoceptor antagonist, powder

Sinónimos:

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

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Tamaño de envase	SKU	Disponibilidad	Precio
250 mg		Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	69,60 €
1 g		Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	114,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₄H₂₀N₂O₂

Número CAS:

13523-86-9

Peso molecular:

248.32

NACRES:

NA.77

PubChem Substance ID:

24277795

UNSPSC Code:

12352200

EC Number:

236-867-9

MDL number:

MFCD00010530

Assay:

≥98% (TLC)

Form:

powder

69,60 €

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Propiedades

Nombre del producto

Pindolol, ≥98% (TLC), powder

Quality Segment

200

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

167-171 °C (lit.)

solubility

0.1 M NaOH: 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, acetic acid: 50 mg/mL, H₂O: insoluble

originator

Novartis

storage temp.

2-8°C

SMILES string

CC(C)NCC(O)COc1cccc2[nH]ccc12

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), HTR1A(3350)

Descripción

Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem/physiol Actions

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

Features and Benefits

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Este artículo	P8688	SML1913	P0884
Sigma-Aldrich P0778 Pindolol	Sigma-Aldrich P8688 (S)-(−)-Propranolol hydrochloride	Sigma-Aldrich SML1913 ASB14780	Sigma-Aldrich P0884 (±)-Propranolol hydrochloride
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥99% (TLC)
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility 0.1 M NaOH: 0.2 mg/mL, 0.1 M HCl: 20 mg/mL, H₂O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL, acetic acid: 50 mg/mL	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL	solubility DMSO: 10 mg/mL, clear	solubility ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
color white to off-white	color -	color white to beige	color white