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Merck

P0643

5-Propyl-2-thiouracil

≥98%

Sinónimos:

PTU

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Fórmula empírica (notación de Hill):
C7H10N2OS
Número CAS:
2954-52-1
Peso molecular:
170.23
NACRES:
NA.51
PubChem Substance ID:
24898118
UNSPSC Code:
41106305
MDL number:
MFCD00057340
Assay:
≥98%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

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InChI key

RWJRFPUNLXBCML-UHFFFAOYSA-N

SMILES string

CCCC1=CNC(=S)NC1=O

InChI

1S/C7H10N2OS/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)

biological source

synthetic (organic)

assay

≥98%

form

powder

solubility

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

Quality Level

100

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Este artículo
C9375T7750P3252
5-Propyl-2-thiouracil ≥98%

Sigma-Aldrich

P0643

5-Propyl-2-thiouracil

5-Carboxy-2-thiouracil

Sigma-Aldrich

C9375

5-Carboxy-2-thiouracil

2-Thiouracil ≥99%

Sigma-Aldrich

T7750

2-Thiouracil

6-Phenyl-2-thiouracil ≥95%

Sigma-Aldrich

P3252

6-Phenyl-2-thiouracil

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic (organic)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

form

powder

form

powder

form

powder

form

powder

assay

≥98%

assay

≥98% (TLC)

assay

≥99%

assay

≥95%

solubility

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow

solubility

1 M NaOH: 50 mg/mL, clear, colorless to faintly yellow

solubility

1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow

solubility

DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow

Application

5-Propyl-2-thiouracil (PTU) is used to induce and study mechanisms of hypothyroidism at the levels of thyroid hormone biosynthesis and gene regulation.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
MKCV5627
MKCV5241
MKCR7389
MKCM8855
MKCB1733V

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Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of bioactive NPs, and the limited biomedical relevance
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With high throughput screening, novel therapeutic agents can be efficiently identified. Unfortunately, researchers only resort to in vitro cell viability assays for screening of anticancer drugs for retinoblastoma, the most common intraocular cancer in the childhood. Current available animal models
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Thyroid hormone (TH) is best known for its role in development in animals, and for its control of metabolic heat production (thermogenesis) during cold acclimation in mammals. It is unknown whether the regulatory role of TH in thermogenesis is derived
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This paper describes a rapid method for confirming residues of thyreostats in meat-based baby foods by using liquid chromatography - dual polarity electrospray - tandem mass spectrometry (LC-ES(±)-MS/MS). Six thioureylenes, belonging to the group of thiouracil and imidazole, were selected
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