As reported in the PROPERTIES section, this product is soluble in H2O at 50 mg/mL yielding a clear, colorless solution.
M4263
Malonyl coenzyme A lithium salt
≥90% (HPLC)
Sinónimos:
Malonyl CoA lithium salt
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 5 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 224,00 € | |
| 10 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 406,00 € | |
| 25 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 557,00 € | |
| 100 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 1690,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C24H38N7O19P3S · xLi+
Número CAS:
Peso molecular:
853.58 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Form:
powder
Assay:
≥90% (HPLC)
Solubility:
H2O: soluble 50 mg/mL protein, clear, colorless
224,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥90% (HPLC)
form
powder
solubility
H2O: soluble 50 mg/mL protein, clear, colorless
storage temp.
−20°C
SMILES string
[Li].CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O
InChI
1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31;/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41);
InChI key
OPIJLICRFQMMJH-UHFFFAOYSA-N
Application
Malonyl coenzyme A lithium salt has been used:
- in Krebs Ringer bicarbonate medium for preincubation of trypsinized and re-suspended fibroblast for fatty acid oxidation assay[1]
- in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer used for scintillation proximity assay for fatty acid synthase
- as an internal standard in the reaction mixture used for succinyl-CoA ligase assay
Biochem/physiol Actions
Malonyl coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Metabolism of glucose also yields malonyl coenzyme A. It allosterically blocks the action of carnitine palmitoyltransferase 1, which affects the transfer of long chain fatty acids into mitochondria. Inactivation of fatty acid synthase results in excess malonyl coenzyme A which leads to anorexia.
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Malonyl Coenzyme A is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl CoA is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
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Este artículo | |||
|---|---|---|---|
| solubility H2O: soluble 50 mg/mL protein, clear, colorless | solubility - | solubility H2O: soluble 100 mg/mL, clear, colorless | solubility - |
| assay ≥90% (HPLC) | assay 97% (CP) | assay ≥93% (HPLC) | assay ≥90% (HPLC) |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form powder | form solid | form powder | form powder |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Artículos
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
R G Summers et al.
Biochemistry, 34(29), 9389-9402 (1995-07-25)
Streptomyces glaucescens, a Gram-positive soil bacterium, produces the polyketide antibiotic tetracenomycin (Tcm) C. To study possible biochemical connections between the biosynthesis of bacterial fatty acids and polyketides, the abundant acyl carrier protein (ACP) detected throughout the growth of the tetracenomycin
J Kalervo Hiltunen et al.
Biochimica et biophysica acta, 1797(6-7), 1195-1202 (2010-03-17)
Recent studies have revealed that mitochondria are able to synthesize fatty acids in a malonyl-CoA/acyl carrier protein (ACP)-dependent manner. This pathway resembles bacterial fatty acid synthesis (FAS) type II, which uses discrete, nuclearly encoded proteins. Experimental evidence, obtained mainly through
Michael J Wolfgang et al.
The FEBS journal, 278(4), 552-558 (2011-01-05)
Metabolic integration of nutrient sensing in the central nervous system has been shown to be an important regulator of adiposity by affecting food intake and peripheral energy expenditure. Modulation of de novo fatty acid synthetic flux by cytokines and nutrient
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| M4263-25MG | 04061834057932 |
| M4263-10MG | 04061834057840 |
| M4263-5MG | 04061834058397 |
| M4263-100MG | 04061834057635 |
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whats the appropriate solvent? PBS? DMSO? DW?
1 respuesta-
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Malonyl Coenzyme A can be store as aqueous solution ?
1 respuesta-
The stability of Malonyl Coenzyme A in aqueous solution has not been determined. However, other sources indicate that prepared solutions may be stable for several months at a minimum of -20 °C.
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