M120
Metaphit methanesulfonate salt
≥98% (HPLC), solid
Sinónimos:
1-[1-(3-Isothiocyanato)phenyl]cyclohexylpiperidine methanesulfonate salt
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Acerca de este artículo
Fórmula lineal:
C18H24N2S · CH3SO3H
Número CAS:
Peso molecular:
396.57
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: >20 mg/mL
storage temp.
−20°C
SMILES string
CS(O)(=O)=O.S=C=Nc1cccc(c1)C2(CCCCC2)N3CCCCC3
InChI
1S/C18H24N2S.CH4O3S/c21-15-19-17-9-7-8-16(14-17)18(10-3-1-4-11-18)20-12-5-2-6-13-20;1-5(2,3)4/h7-9,14H,1-6,10-13H2;1H3,(H,2,3,4)
InChI key
ZASHKPXYYPYQRI-UHFFFAOYSA-N
Gene Information
human ... OPRS1(10280)
Biochem/physiol Actions
Metaphit methanesulfonate salt is an irreversible, non-competitive antagonist at the phencyclidine site on the NMDA receptor; sigma receptor irreversible, competitive antagonist.
Disclaimer
Hygroscopic
Clase de almacenamiento
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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E D French et al.
European journal of pharmacology, 140(3), 267-274 (1987-08-21)
Metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, has been considered as a potentially specific PCP antagonist. In whole animal studies, however, metaphit has been shown to have either
L S Bluth et al.
European journal of pharmacology, 161(2-3), 273-277 (1989-02-28)
Pretreatment of guinea pig brain membranes with 1-[1-(3-isothiocyanatophenyl)cyclohexyl]piperidine (Metaphit) caused irreversible and differential inhibition of ligand binding to sigma (sigma) receptors. The concentration of Metaphit required to produce 50% inhibition of binding of [3H]1,3-di-o-tolylguanidine ([3H]DTG), [3H](+)-3-(3-hydroxy-phenyl)-N-(1-propyl)piperidine ([3H](+)-3-PPP), and [3H](+)-N-allylnormetazocine ([3H](+)-SKF
I Zimányi et al.
Synapse (New York, N.Y.), 3(3), 239-245 (1989-01-01)
[3H]Mazindol was used to label the dopamine uptake complex in mouse striatum in vitro in the presence and absence of metaphit, an isothiocyanate derivative of phencyclidine. In some experiments, metaphit was present in the incubation fluid throughout the procedure; in