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J4145

Jervine

≥98% (HPLC), powder

Sinónimos:

(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine

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Tamaño de envaseSKUDisponibilidadPrecio
1 mg
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190,00 €
161,50 €

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Fórmula empírica (notación de Hill):
C27H39NO3
Número CAS:
469-59-0
Peso molecular:
425.60
NACRES:
NA.77
PubChem Substance ID:
24896194
UNSPSC Code:
51111800
EC Number:
207-417-9
MDL number:
MFCD01684066
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

161,50 €

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Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

methanol: >2 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

[H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(=C3C)C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)O2

InChI

1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1

InChI key

CLEXYFLHGFJONT-DNMILWOZSA-N

Gene Information

human ... EBP(10682)

General description

Jervine is a steroid alkaloid present in Veratrum californicum.[1][2]

Biochem/physiol Actions

Jervine is a potent teratogenic agent.[3] It can induce apoptosis in leukemia cells[1] and MUTZ-1 cells. Jervine is an inhibitor of Hedgehog signaling. It exhibits anti-cancer effects on human prostate cancer. It also increases the chemosensitivity of breast cancer cells to doxorubicin treatment.[2] Jervine may be used for treating hypertension and heart disease.[3]
Jervine is a sonic hedgehog (Shh) pathway inhibitor.

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Este artículo
C4116PHL83515SML0147
Jervine ≥98% (HPLC), powder

Sigma-Aldrich

J4145

Jervine

Cyclopamine hydrate ≥98% (HPLC)

Sigma-Aldrich

C4116

Cyclopamine hydrate

Jervine phyproof® Reference Substance

PHL83515

Jervine

Drospirenone ≥98% (HPLC)

Sigma-Aldrich

SML0147

Drospirenone

form

powder

form

solid

form

-

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

methanol: >2 mg/mL, H2O: insoluble

solubility

DMSO: soluble ≥5 mg/mL, H2O: insoluble

solubility

-

solubility

DMSO: ≥15

Gene Information

human ... EBP(10682)

Gene Information

human ... EBP(10682)

Gene Information

-

Gene Information

human ... NR3C2(4306), PGR(5241)

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1B

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
062M4709V
081M4727V
019K4707
057K4710
104K4703

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Artículos

Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

K A El Sayed et al.
Phytochemistry, 55(1), 19-22 (2000-10-06)
Preparative-scale fermentation of the known C-nor-D-homosteroidal jerveratrum alkaloid jervine with Cunninghamella elegans (ATCC 9245) has resulted in the isolation of (-)-jervinone as the major metabolite. In addition, C. elegans ATCC 9245 was able to epimerize C-3 of jervine, producing 3-epi-jervine.
Carlos M Moran et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 240(6), 1354-1364 (2011-03-09)
Signaling by the hedgehog (Hh) family of secreted growth factors is essential for development of embryonic blood vessels. Embryos lacking Hh function have abundant endothelial cells but fail to assemble vascular cords or lumenized endothelial tubes. However, the role of
Lamia Ghezali et al.
Experimental cell research, 319(7), 1043-1053 (2013-01-30)
Erythroleukemia is generally associated with a very poor response and survival to current available therapeutic agents. Cyclooxygenase-2 (COX-2) has been described to play a crucial role in the proliferation and differentiation of leukemia cells, this enzyme seems to play an
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SKUGTIN
J4145-1MG04061826675540

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