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Merck

I9783

Sigma-Aldrich

Monoclonal Anti-Importin α3 antibody produced in rat

clone 3D10, purified immunoglobulin, buffered aqueous solution

Sinónimos:

Anti-Imp α

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rat

conjugado

unconjugated

forma del anticuerpo

purified immunoglobulin

tipo de anticuerpo

primary antibodies

clon

3D10, monoclonal

formulario

buffered aqueous solution

mol peso

antigen ~60 kDa

reactividad de especies

mouse, hamster, bovine, canine, rat, human, monkey

técnicas

microarray: suitable
western blot: 2-4 μg/mL using HeLa cell extract

isotipo

IgG2a

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... KPNA4(3840)
mouse ... Kpna4(16649)
rat ... Kpna4(361959)

Inmunógeno

recombinant mouse importin α3/Qip1.

Acciones bioquímicas o fisiológicas

The gene KPNA4 (karyopherin subunit α 4) encodes a 16kDa protein, also referred to as importin α 3 belonging to the family of karyopherins (designated KPNA1 to KPNA4), that participates in the recognition of NLS (nuclear localization signal) sites and dock NLS-containing proteins destined for transport into the nuclear pore complex. It binds to translocon and participates in the sorting of INM (inner nuclear membrane)-directed integral membrane proteins. It associates with nucleoporins and functions in cargo-translocation across the nuclear membrane.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

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KPNA4 Mediates Vitamin D-Dependent Inhibition of NF-kB Activity in Swine Epicardial Preadipocytes.
Chen S
Circulation, A12818-A12818 (2014)
Matthew Frieman et al.
Journal of virology, 81(18), 9812-9824 (2007-06-29)
The host innate immune response is an important deterrent of severe viral infection in humans and animals. Nuclear import factors function as key gatekeepers that regulate the transport of innate immune regulatory cargo to the nucleus of cells to activate
Sharon C Braunagel et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(22), 9307-9312 (2007-05-23)
Spodoptera frugiperda (Sf9) importin-alpha-16 is a translocon-associated protein that participates in the early sorting pathway of baculovirus integral membrane proteins destined for the inner nuclear membrane (INM). To discern whether sorting intermediate protein complexes like those observed in insect cells
Annett Koch et al.
Cell cycle (Georgetown, Tex.), 10(8), 1200-1207 (2011-03-18)
It is well established that mutual relations exist between the oxidative status of a cell and the ubiquitin proteasome system (UPS). Oxidation of proteins leads to misfolding and thus claims a higher proteolytic activity of the UPS to dispose these

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