I8250

3-Iodo-L-tyrosine

• Sinónimos: 3-Monoiodo-L-tyrosine
• Fórmula lineal: IC₆H₃-4-(OH)CH₂CH(NH₂)CO₂H
• Número de CAS: 70-78-0
• Peso molecular: 307.09
• Beilstein: 2941266
• Número CE: 200-744-8
• Número MDL: MFCD00002608
• Código UNSPSC: 12352200
• eCl@ss: 32160406
• ID de la sustancia en PubChem: 24278154
• NACRES: NA.32

Propiedades

• impurezas: ~5% tyrosine
• mp: 210 °C (dec.) (lit.)
• solubilidad: dilute aqueous acid: soluble
• temp. de almacenamiento: −20°C
• cadena SMILES: N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O
• InChI: 1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
• Clave InChI: UQTZMGFTRHFAAM-ZETCQYMHSA-N
• Información sobre el gen: human ... TH(7054)

Descripción

Descripción general

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).

Aplicación

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Acciones bioquímicas o fisiológicas

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset.

Tyrosine hydroxylase inhibitor.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)