I7378

Indomethacin

98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor

• Sinónimos: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
• Fórmula empírica (notación de Hill): C₁₉H₁₆ClNO₄
• Número de CAS: 53-86-1
• Peso molecular: 357.79
• Beilstein: 497341
• Número CE: 200-186-5
• Número MDL: MFCD00057095
• Código UNSPSC: 12161501
• ID de la sustancia en PubChem: 24278173
• NACRES: NA.77

Propiedades

• product name: Indomethacin, 98.5-100.5% (in accordance with EP)
• origen biológico: synthetic
• Nivel de calidad: 200
• Análisis: 98.5-100.5% (in accordance with EP)
• formulario: powder or crystals
• pérdida: ≤0.5% loss on drying
• mp: 158-162 °C
• Modo de acción: enzyme | inhibits
• cadena SMILES: COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
• InChI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
• Clave InChI: CGIGDMFJXJATDK-UHFFFAOYSA-N
• Información sobre el gen: human ... ALB(213) , ALOX5(240) , ELA2(1991) , GPR44(11251) , IL1A(3552) , PLA2G1B(5319) , PTGDR(5729) , PTGS1(5742) , PTGS2(5743) ; mouse ... Alox5(11689) , Ptgdr(19214) , Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219) , Ptgs1(19224) ; rat ... Alox5(25290) , Ptgs1(24693) , Ptgs2(29527)

Descripción

Descripción general

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.

Aplicación

Indomethacin has been used:

• as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
• as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
• in the inhibition of prostaglandin E2 (PGE2) in T cells

Acciones bioquímicas o fisiológicas

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 1 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges