Documentos clave

Ver Toda la documentación

Saltar a

E8375

Eserine

Name: Eserine
Brand: SIGMA

Sinónimos:

Physostigmine

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Cambiar Vistas

Tamaño de envase	SKU	Disponibilidad	Precio

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₅H₂₁N₃O₂

Número CAS:

57-47-6

Peso molecular:

275.35

EC Number:

200-332-8

UNSPSC Code:

12352200

PubChem Substance ID:

24277867

Beilstein/REAXYS Number:

91230

MDL number:

MFCD00151090

En este momento no podemos mostrarle ni los precios ni la disponibilidad

Servicio técnico

¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.

Permítanos ayudarle

Propiedades

assay

≥99% (HPLC)

mp

102-104 °C (lit.)

SMILES string

[H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)NC)ccc3N2C

InChI

1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1

InChI key

PIJVFDBKTWXHHD-HIFRSBDPSA-N

Gene Information

human ... ACHE(43), APP(351), BCHE(590)
mouse ... Ache(11423), Bche(12038), Chrm1(12669)
rat ... Ache(83817), Bche(65036), Chrm2(81645)

Descripción

Biochem/physiol Actions

Acetylcholinesterase inhibitor that crosses the blood-brain barrier and forms a carbamylated enzyme complex with acetyl cholinesterase that degrades slowly.

Acetylcholinesterase inhibitor that crosses the blood-brain barrier.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Acetylcholine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS06

signalword

Danger

hcodes

H300 + H330

pcodes

P301 + P310 + P330 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Clase de almacenamiento

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.

Federica Belluti et al.

Journal of medicinal chemistry, 48(13), 4444-4456 (2005-06-25)

In continuing research that led us to identify a new class of carbamate derivatives acting as potent (Rampa et al. J. Med. Chem. 1998, 41, 3976) and long-lasting (Rampa et al. J. Med. Chem. 2001, 44, 3810) acetylcholinesterase (AChE) inhibitors

Imaging changes in synaptic acetylcholine availability in living human subjects.

Irina Esterlis et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(1), 78-82 (2012-11-20)

In vivo estimation of β(2)-nicotinic acetylcholine receptor availability with molecular neuroimaging is complicated by competition between the endogenous neurotransmitter acetylcholine and the radioligand (123)I-3-[2(S)-2-azetidinylmethoxy]pyridine ((123)I-5-IA). We examined whether binding of (123)I-5-IA is sensitive to increases in extracellular levels of acetylcholine

Partial antagonism of propofol anaesthesia by physostigmine in rats is associated with potentiation of fast (80-200 Hz) oscillations in the thalamus.

S J Reed et al.

British journal of anaesthesia, 110(4), 646-653 (2012-12-06)

Positron emission tomography studies in human subjects show that propofol-induced unconsciousness in humans is associated with a reduction in thalamic blood flow, suggesting that anaesthesia is associated with impairment of thalamic function. A recent study showed that antagonism of propofol-induced