E7265
Big Endothelin 39 rat
≥97% (HPLC)
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 0.1 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 529,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C192H292N50O58S5
Número CAS:
Peso molecular:
4389.00
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Assay:
≥97% (HPLC)
Quality level:
529,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥97% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
rat ... Edn1(24323)
General description
Big endothelin-1 is a 39 amino acid peptide, which is synthesized and secreted by vascular smooth muscle and endothelium cells. It is produced as an inactive enzyme, and is cleaved and activated by serine and aspartic proteases and metalloproteinases. Activated form is called ET-1, which is a potent vasoconstrictor. ET-1 is also produced by the action of endothelin converting enzyme (ECE) on big-ET-1. In guinea pigs, big-ET-1 causes the release of prostanoids and thromboxanes.[1][2][3]
Application
Big Endothelin 39 rat has been used for charting of a standard curve in the study of the role of ET-1 in ventricular dilatation.[4]
Biochem/physiol Actions
Precursor of Endothelin-1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.
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Este artículo | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information rat ... Edn1(24323) | Gene Information human ... EDN1(1906) | Gene Information human ... EDN2(1907) | Gene Information human ... EDN3(1908) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
Clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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D Fraccarollo et al.
Circulation, 96(11), 3963-3973 (1997-12-24)
Left ventricular dilatation after myocardial infarction is associated with impaired ventricular function and heart failure and has important implications for survival. The purpose of this study was to investigate the role of endothelin-1 (ET-1) in ventricular dilatation and the effects
S Lehoux et al.
British journal of pharmacology, 107(4), 996-1000 (1992-12-01)
1. Changes in vascular permeability following intravenous injections of human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) were measured by extravasation of Evans blue dye (EB, 20 mg kg-1) in selected tissues. 2. A low dose of big-ET-1 (40 pmol kg-1) failed
E G McMahon et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(3), 703-707 (1991-02-01)
In porcine aortic endothelial cells, the 21-amino acid peptide endothelin-1 (ET-1) is formed from a 39-amino acid intermediate called "big endothelin-1" (big ET-1) by a putative ET-converting enzyme (ECE) that cleaves the 39-mer at the bond between Trp-21 and Val-22.
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| E7265-.1MG | 04061832676760 |