E3256
Edrophonium chloride
Sinónimos:
Ethyl(m-hydroxyphenyl)dimethylammonium chloride
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About This Item
Fórmula empírica (notación de Hill):
C10H16ClNO
Número de CAS:
Peso molecular:
201.69
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
cadena SMILES
[Cl-].CC[N+](C)(C)c1cccc(O)c1
InChI
1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
Clave InChI
BXKDSDJJOVIHMX-UHFFFAOYSA-N
Información sobre el gen
human ... ACHE(43)
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Acciones bioquímicas o fisiológicas
Acetycholinesterase inhibitor
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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James Rook et al.
Pediatric emergency care, 26(5), 374-375 (2010-05-11)
Myasthenia gravis is a rare, chronic, autoimmune disorder characterized by postsynaptic dysfunction at the neuromuscular junction. The disease affects more females than males. We describe the case of a 17-year-old female adolescent with recurrent episodes of dysarthria and dysphagia and
Mathilde M Triquigneaux et al.
The Biochemical journal, 448(1), 83-91 (2012-08-15)
The principal role of AChE (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. The active site of AChE is near the bottom of a long and narrow gorge lined with aromatic residues.
Yuu Yamazaki et al.
Internal medicine (Tokyo, Japan), 49(1), 69-72 (2010-01-05)
We describe a 52-year-old man with a history of increasing fatigability and gait disturbances that were first attributed to hypothyroidism. On examination, he had bilateral pseudo-internuclear ophthalmoplegia with weakness of adduction and abducting nystagmus. Convergence was also impaired and he
Shin J Oh et al.
Muscle & nerve, 39(3), 328-332 (2009-01-08)
Demographic, clinical, and laboratory features were compared in 235 white and African-American (AA) patients with myasthenia gravis (MG) at the University of Alabama at Birmingham Neuromuscular Disease Clinic from May 2003 to January 2008. Seventy nine percent of patients were
Francesco Leonetti et al.
Bioorganic & medicinal chemistry, 16(15), 7450-7456 (2008-07-01)
A number of mono- and bis-quaternary ammonium salts, containing edrophonium-like and coumarin moieties tethered by an appropriate linker, proved to be highly potent and selective dual binding site acetylcholinesterase inhibitors with good selectivity over butyrylcholinesterase. Homobivalent bis-quaternary inhibitors 11 and
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