E0407

Estramustine sodium phosphate

• Sinónimos: Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate) sodium salt, Estra-1,3,5(10)triene-3,17β-diol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) sodium salt
• Fórmula empírica (notación de Hill): C₂₃H₃₀Cl₂NNa₂O₆P
• Número CAS: 52205-73-9
• Peso molecular: 564.35
• NACRES: NA.28
• PubChem Substance ID: 329798968
• UNSPSC Code: 51111800
• EC Number: 257-735-7
• MDL number: MFCD00866320
• Form: powder
• Assay: ≥85.0% (HPLC)

Propiedades

• assay: ≥85.0% (HPLC)
• form: powder
• solubility: H₂O: 50 mg/mL
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@]12[C@@]([C@@](CC[C@@H]3OP([O-])([O-])=O)([H])[C@]3(C)CC2)([H])CCC4=C1C=CC(OC(N(CCCl)CCCl)=O)=C4.[Na+].[Na+]
• InChI: 1S/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/q;2*+1/p-2/t18-,19-,20+,21+,23+;;/m1../s1
• InChI key: IIUMCNJTGSMNRO-VVSKJQCTSA-L
• Gene Information: human ... ESR2(2100)

Descripción

Biochem/physiol Actions

Estradiol mustard prodrug which binds estradiol receptors irreversibly. Alkylating compound used as an antineoplastic agent against prostate cancer. Depolymerizes microtubules by binding to microtubule associated proteins (MAPs).

Estradiol mustard prodrug, which binds estradiol receptors irreversibly. Highly effective in treatment of advanced metastatic prostate cancer. Depolymerizes microtubules by binding to microtubule associated proteins (MAPs).

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves