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C8114

Sigma-Aldrich

Anti-α-E-Catenin antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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About This Item

Número MDL:
MFCD05665180
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 102 kDa

reactividad de especies

rat, human, canine

técnicas

immunocytochemistry: 1:200 using methanol-fixed, dog MDCK and human MCF7 cellc
microarray: suitable
western blot: 1:1,000 using whole cell extract of human epidermal carcinoma A431 cell line and cytosolic fraction of rat embryonic brain.

Nº de acceso UniProt

P35221

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... CTNNA1(1495)
rat ... Ctnna1(307505)

Descripción general

α-E-Catenin is a predominant subtype of α-catenin. It is widely expressed but at low levels in the nervous system. Alternative spliced variants of α-E-Catenin include α1- and α2-E-catenin.
The catenins (α, β, γ) are cytoplasmic proteins found in varying abundance in many developing and adult tissues.

Inmunógeno

synthetic peptide corresponding to a region located near the C-terminus of human α-E-catenin (amino acids 873-887). This sequence is identical in mouse and Xenopus α-E-catenin. It is not found in α-N-catenin, β-catenin, and γ-catenin.

Aplicación

Anti-α-E-Catenin antibody produced in rabbit has been used in western blotting and immunocytochemistry.

Acciones bioquímicas o fisiológicas

Catenins bind directly or indirectly to the conserved cytoplasmic tail domain of the cell adhesion adherins. The association of catenins to cadherins produces a complex, which is linked to the actin filament network. Catenins/cadherin complexes play an important role in mediating cell adhesion, transduction of cell-cell contact positional signals to the cell interior, and may play a crucial role in cell differentiation. The linkage of the epithelial cadherin /uvomorulin to actin is essential for the cell binding function of this cadherin. α-Catenin (CAP102, 102 kDa), originally described as an E-cadherin associated protein, has been shown to associate with other members of the cadherin family members, N-cadherin and P-cadherin. Within its conserved region α-catenin shows 30% identity to vinculin.

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Evolving form to fit function: cardiomyocyte intercalated disc and transverse-tubule membranes
Current Topics in Membranes, 72, 121-158 (2013)
p120 catenin is required for normal renal tubulogenesis and glomerulogenesis
Marciano DK, et al.
Development, 138(10), 2099-2109 (2011)
K Herrenknecht et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(20), 9156-9160 (1991-10-15)
The cytoplasmic region of the Ca(2+)-dependent cell-adhesion molecule (CAM) uvomorulin associates with distinct cytoplasmic proteins with molecular masses of 102, 88, and 80 kDa termed alpha, beta, and gamma catenin, respectively. This complex formation links uvomorulin to the actin filament
Krishnanand Padmanabhan et al.
Development (Cambridge, England), 147(23) (2020-12-15)
Planar cell polarity (PCP) is essential for tissue morphogenesis and homeostasis; however, the mechanisms that orchestrate the cell shape and packing dynamics required to establish PCP are poorly understood. Here, we identified a major role for the globular (G)-actin-binding protein
Arad Soffer et al.
PLoS biology, 20(8), e3001756-e3001756 (2022-08-16)
Mitotic spindle orientation (SO) is a conserved mechanism that governs cell fate and tissue morphogenesis. In the developing epidermis, a balance between self-renewing symmetric divisions and differentiative asymmetric divisions is necessary for normal development. While the cellular machinery that executes
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