C7482
Caspase 6 human
recombinant, expressed in E. coli, >90% (SDS-PAGE), lyophilized powder, 13,000 units/mg protein
Sinónimos:
Mch2
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NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
13,000 units/mg protein
Assay:
>90% (SDS-PAGE)
Recombinant:
expressed in E. coli
recombinant
expressed in E. coli
Quality Level
assay
>90% (SDS-PAGE)
form
lyophilized powder
specific activity
13,000 units/mg protein
mol wt
~30 kDa
solubility
PBS: soluble
shipped in
dry ice
storage temp.
−70°C
Biochem/physiol Actions
Cleaves the substrates consisting of consensus sequence VEID.
Spontaneously undergoes autoprocessing to yield the subunits associated to form the active enzyme.
Useful in screening caspase inhibitors, studying enzyme regulation, determining specificity of caspase substrates, or as a positive control in caspase activity assays.
Physical form
Contains 0.052% ammonium sulfate, 0.158% Tris−HCl, 0.76% sodium chloride.
Other Notes
One unit will hydrolyze 1 nmol of the caspase substrate VEID-pNA to VEID and p-nitroaniline per hour at pH 7.2 at 37 °C.
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|---|---|---|---|
| specific activity 13,000 units/mg protein | specific activity ≥6000 units/mg protein | specific activity ≥25,000 units/mg protein, ≥50,000 units/mL | specific activity ≥1.0 units/mg protein |
| assay >90% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥85% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli (C-terminal histidine-tagged) |
| form lyophilized powder | form lyophilized | form liquid | form buffered aqueous glycerol solution |
| mol wt ~30 kDa | mol wt - | mol wt - | mol wt ~30 kDa |
| solubility PBS: soluble | solubility - | solubility - | solubility - |
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Ana A Baburamani et al.
Developmental neuroscience, 37(4-5), 321-337 (2015-04-01)
Apoptotic mechanisms are centre stage for the development of injury in the immature brain, and caspases have been shown to play a pivotal role during brain development and in response to injury. The inhibition of caspases using broad-spectrum agents such