C4249
Cystatin B human
recombinant, expressed in E. coli, solid, ≥95% (SDS-PAGE)
Sinónimos:
CPI-B, CST6, CSTB, EPM1, Liver Thiol Proteinase Inhibitor, PME, STFB, Stefin B
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 50 μg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 634,00 € 538,90 € |
Acerca de este artículo
UNSPSC Code:
12352202
NACRES:
NA.77
538,90 €
Precio de catálogo634,00 €Ahorre 15 %Promoción solo por Internet
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Permítanos ayudarleNombre del producto
Cystatin B human, recombinant, expressed in E. coli
recombinant
expressed in E. coli
Quality Level
description
contains a N-terminal 7X His-tag
assay
≥95% (SDS-PAGE)
form
solid
mol wt
apparent mol wt ~13 kDa by SDS-PAGE (reducing)
NCBI accession no.
storage temp.
−20°C
Gene Information
human ... CSTB(1476)
General description
Cystatin B is a member of the type 1 (stefins) superfamily of cystatins. Cystatin B is encoded by the CSTB gene and functions as an intracellular thiol protease inhibitor regulating the activity of members of the papain family and cathepsins B, H, and L. Cystatin B may also protect cellular components from the effects of proteases that leak from lysosomes. Mutations in the CSTB gene are thought to be the primary defect in patients with Progressive Myoclonus Epilepsy (EPM1).
Application
Suitable for use as a cysteine-protease inhibitor. Is tested for suitability as an inhibitor of the enzymatic activity of papain.
Biochem/physiol Actions
Cystatin B was shown to interact with the protein RACK-1, β-spectrin and neurofilament light chain NF-L forming a unique multiprotein complex specifically in the cerebellum, confirming its function in the brain. [1]
Preparation Note
Cystatin B should be reconstituted at 100 μg/mL in steile 25 mM Tris pH 7.5 and 100 mM NaCl. Reconstituted product should be stored in single-use aliquots at -70° C and should be stable for at least 3 months.
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Este artículo | |||
|---|---|---|---|
| assay ≥95% (SDS-PAGE) | assay - | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| Gene Information human ... CSTB(1476) | Gene Information human ... CSTB(1476) | Gene Information human ... CST3(1471) | Gene Information human ... CTSB(1508) |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| form solid | form buffered aqueous solution | form lyophilized powder | form liquid |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −70°C |
| mol wt apparent mol wt ~13 kDa by SDS-PAGE (reducing) | mol wt - | mol wt - | mol wt - |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Rossella Di Giaimo et al.
Human molecular genetics, 11(23), 2941-2950 (2002-10-24)
Cystatin B is an anti-proteolytic polypeptide implicated in progressive myoclonus epilepsy (EPM1), a degenerative disease of the central nervous system. The knock-out mouse model of the disease shows apoptosis of the cerebellar granule cells. We have identified five recombinant proteins
Hana Dvořáková et al.
Frontiers in cellular and infection microbiology, 10, 66-66 (2020-03-17)
Schistosomula (the post-infective stages) of the neurotropic schistosome Trichobilharzia regenti possess multiple isoforms of cathepsin B1 peptidase (TrCB1.1-TrCB1.6) with involvement in nutrient digestion. The comparison of substrate preferences of TrCB1.1 and TrCB1.4 showed that TrCB1.4 had a very narrow substrate
Amanda Phuong Tran et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(23), 5399-5414 (2018-05-16)
Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. Chondroitin sulfate proteoglycans (CSPGs) are the major axon inhibitory matrix component that is increased within
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| C4249-50UG | 04061833217979 |