C1538

Complement C8 deficient serum human

for complement assays

• NACRES: NA.61
• UNSPSC Code: 12352202
• Biological source: human
• Origin: USA origin
• Form: solution
• Shipped in: dry ice

Propiedades

• biological source: human
• Quality Segment: 200
• form: solution
• origin: USA origin
• technique(s): activity assay: suitable
• impurities: infectious agent, tested
• UniProt accession no.: P07357
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... C8A(731)

Descripción

Application

Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C8 may result in an increased susceptibility to Neisseria meningitidis. The most common mutation resulting in a C8 deficiency is a C to T transition in exon 9 of the C8 beta gene. Recent research however, has also discovered that two separate heterogeneous mutations may result in C8 deficiency in patients displaying recurrent meningococcal meningitis. These mutations are a duplication mutation on exon 7 and a mutation on exon 3.

Biochem/physiol Actions

Serum naturally deficient in C8 may actually contain some C8, though in greatly reduced quantity. Terminal complement complex is present at trace levels in such sera.[1]

Physical form

Supplied as a solution in PBS, pH 7.3

Analysis Note

C8 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Clase de almacenamiento: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable