C0871
Anti-Cullin 3 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-CUL3
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Acerca de este artículo
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
12
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Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~80 kDa
species reactivity
rat, mouse, human
concentration
~1.0 mg/mL
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Este artículo | |||
|---|---|---|---|
| antibody form affinity isolated antibody | antibody form purified from hybridoma cell culture | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| biological source rabbit | biological source mouse | biological source rabbit | biological source rabbit |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| species reactivity rat, mouse, human | species reactivity rat, human, mouse | species reactivity human, mouse | species reactivity human |
| clone polyclonal | clone CUL3-9, monoclonal | clone polyclonal | clone polyclonal |
General description
Cullin 3 is a member of the cullin family of E3 ubiquitin protein ligases. Cullin 3 forms the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase complex that contains a RING-box protein, Rbx1, and a BTB containing protein. Rbx1 binds to the C-terminus of cullin 3 through its RING-type zinc finger domain to recruit a ubiquitin-conjugating enzyme. The BTB containing protein binds cullin 3 at its N-terminus and functions as a cullin specific adaptor protein.
Application
Anti-Cullin 3 antibody produced in rabbit has been used in
- western blotting[1]
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Cullin 3 (Cul3) acts as a key mediator of post-translational protein regulation. It functions as a scaffold protein that assemble multi-subunit ubiquitin ligase complexes which are responsible for the specific recognition and targeting of substrates for ubiquitin-dependent degradation by the 26S proteasome. Cul3 is required for degradation of the microtubule-severing protein MEI-1/katanin during transitioning from meiosis-to-mitosis phase. It forms a catalytically inactive BTB-Cul3-Rbx1 (BCR) ubiquitin ligase and becomes functional upon covalent attachment of the ubiquitin homologue neural-precursor-cell-expressed. BCR ubiquitin ligase down regulated 8 (Nedd8) near the C terminus of Cul3.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clase de almacenamiento
12 - Non Combustible Liquids
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Missense variants in RHOBTB2 cause a developmental and epileptic encephalopathy in humans, and altered levels cause neurological defects in Drosophila
Straub J, et al.
American Journal of Human Genetics, 102(1), 44-57 (2018)
Matthew D Petroski et al.
Nature reviews. Molecular cell biology, 6(1), 9-20 (2005-02-03)
Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key
J D Singer et al.
Genes & development, 13(18), 2375-2387 (1999-09-29)
Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome- dependent pathway. Two factors stimulate cyclin E ubiquitination in vivo: when it is free of its CDK partner, and when it is phosphorylated on threonine 380.
Lionel Pintard et al.
The EMBO journal, 23(8), 1681-1687 (2004-04-09)
Cullin-based E3 ligases target substrates for ubiquitin-dependent degradation by the 26S proteasome. The SCF (Skp1-Cul1-F-box) and ECS (ElonginC-Cul2-SOCS box) complexes are so far the best-characterized cullin-based ligases. Their atomic structure has been solved recently, and several substrates have been described
Wananit Wimuttisuk et al.
Molecular biology of the cell, 18(3), 899-909 (2006-12-29)
Cullins are members of a family of scaffold proteins that assemble multisubunit ubiquitin ligase complexes to confer substrate specificity for the ubiquitination pathway. Cullin3 (Cul3) forms a catalytically inactive BTB-Cul3-Rbx1 (BCR) ubiquitin ligase, which becomes functional upon covalent attachment of
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| C0871-200UL | 04061838030306 |
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