Saltar al contenido
Merck
Todas las fotos(1)

Documentos

B8810

Sigma-Aldrich

BAY 41-2272

≥97% (HPLC)

Sinónimos:

3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C20H17FN6
Número de CAS:
256376-24-6
Peso molecular:
360.39
Número MDL:
MFCD06411391
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24892096
NACRES:
NA.77

Análisis

≥97% (HPLC)

formulario

powder

color

white to light brown

mp

210.5-211.4 °C

solubilidad

DMSO: 5 mg/mL, clear (warmed)

emisor

Bayer

temp. de almacenamiento

2-8°C

cadena SMILES

Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35

InChI

1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)

Clave InChI

ATOAHNRJAXSBOR-UHFFFAOYSA-N

Aplicación

BAY 41-2272 has been used for the stimulation of guanylate cyclase in heart and neurons.

Acciones bioquímicas o fisiológicas

BAY 41-2272 is an activator of soluble guanylate cyclase at a novel, NO-independent regulatory site. BAY 41-2272 is the first product that stimulates sGC through a non-NO mechanism. BAY 41-2272 inhibits platelet aggregation and induces vasorelaxation without nitrate tolerance.

Características y beneficios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Katalin Bartus et al.
PloS one, 8(2), e57292-e57292 (2013-03-02)
In the hippocampus, as in many other CNS areas, nitric oxide (NO) participates in synaptic plasticity, manifested as changes in pre- and/or postsynaptic function. While it is known that these changes are brought about by cGMP following activation of guanylyl
Female sexual behavior in mice is controlled by kisspeptin neurons
Hellier V, et al.
Nature Communications, 9(1), 400-400 (2018)
Traci R Tuttle et al.
Cancer letters, 389, 33-40 (2016-12-28)
Head and neck squamous cell carcinoma (HNSCC) is an aggressive and often fatal disease. Cisplatin is the most common chemotherapeutic drug in the treatment of HNSCC, but intrinsic and acquired resistance are frequent, and severe side effects occur at high
Benjamin Vandendriessche et al.
PloS one, 8(8), e72155-e72155 (2013-09-10)
Sepsis and septic shock are associated with high mortality rates and the majority of sepsis patients die due to complications of multiple organ failure (MOF). The cyclic GMP (cGMP) producing enzyme soluble guanylate cyclase (sGC) is crucially involved in the
Jennifer C Irvine et al.
PloS one, 7(11), e44481-e44481 (2012-11-13)
Although evidence now suggests cGMP is a negative regulator of cardiac hypertrophy, the direct consequences of the soluble guanylyl cyclase (sGC) activator BAY 58-2667 on cardiac remodeling, independent of changes in hemodynamic load, has not been investigated. In the present
Ver todos los artículos relacionados

Artículos

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico