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B2929

B-Lymphocyte Chemoattractant human

Name: B-Lymphocyte Chemoattractant human
Brand: SIGMA
Price: 640 EUR

≥95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

B-Cell Attracting Chemokine 1, BCA-1, BLC

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Tamaño de envase	SKU	Disponibilidad	Precio
25 μg		Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	640,00 €

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UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD01867020

Biological source:

human

Recombinant:

expressed in E. coli

Assay:

≥95% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

apparent mol wt 8.7 kDa by SDS-PAGE (reducing)

Impurities:

endotoxin, tested

640,00 €

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Propiedades

biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

0.1000 μg/mL

mol wt

apparent mol wt 8.7 kDa by SDS-PAGE (reducing)

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

O43927

storage temp.

−20°C

Gene Information

human ... CXCL13(10563)

Descripción

Biochem/physiol Actions

BCA-1 is a potent chemoattractant for B lymphocytes, but not T lymphocytes, monocytes, or neutrophils.

BCA-1 is a potent chemoattractant for B lymphocytes, but not T lymphocytes, monocytes, or neutrophils. Its specific receptor BLR1 is a G protein-coupled receptor originally isolated from Burkitt′s lymphoma cells. Among cells of the hematopoietic lineages, the expression of BRL1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.

Potent chemoattractant for B lymphocytes, but not T lymphocytes, monocytes, or neutrophils.

The biological activity of human BLC/BCA-1 is measured by its ability to chemoattract mouse BaF/3 cells transfected with human CXCR5.

Physical form

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% TFA containing 50 μg bovine serum albumin per 1 μg of cytokine.

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Este artículo	C8615	I5403	SRP3111
Sigma-Aldrich B2929 B-Lymphocyte Chemoattractant human	Sigma-Aldrich C8615 CXCL16 human	Sigma-Aldrich I5403 Insulin-Like Growth Factor Binding Protein-2 human	Sigma-Aldrich SRP3111 MDC (67 aa) (CCL22) human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay ≥95% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in NSO cells	recombinant expressed in E. coli
biological source human	biological source human	biological source human	biological source human
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level -
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized

pictograms

GHS07

signalword

Warning

hcodes

H302 + H332,H319

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

pcodes

P261 - P264 - P271 - P301 + P312 - P304 + P340 + P312 - P305 + P351 + P338

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Julia Miriam Weiss et al.

Oncotarget, 7(7), 7550-7562 (2016-01-16)

Abnormal overexpression of CXCL13 is observed in many inflamed tissues and in particular in autoimmune diseases. Myasthenia gravis (MG) is a neuromuscular disease mainly mediated by anti-acetylcholine receptor autoantibodies. Thymic hyperplasia characterized by ectopic germinal centers (GCs) is a common

B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.

D F Legler et al.

The Journal of experimental medicine, 187(4), 655-660 (1998-03-28)

Although most leukocytes, T lymphocytes in particular, respond to several different chemokines, there is virtually no information on chemokine activities and chemokine receptors in B lymphocytes. A putative chemokine receptor, BLR1, that is expressed in Burkitt's lymphoma cells and B

A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen.

R Förster et al.

Cell, 87(6), 1037-1047 (1996-12-13)

We describe the phenotype of gene-targeted mice lacking the putative chemokine receptor BLR1. In normal mice, this receptor is expressed on mature B cells and a subpopulation of T helper cells. Blr1 mutant mice lack inguinal lymph nodes and possess

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SKU	GTIN
B2929-25UG	04061833427217

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