B0684
Anti-Bad antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinónimos:
Anti-BBC2, Anti-BCL2L8
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
formulario
lyophilized powder
reactividad de especies
mouse, human
técnicas
western blot: 1 μg/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... BAD(572)
mouse ... Bad(12015)
Categorías relacionadas
Descripción general
Bad (Bcl-2-antagonist of cell death), initially identified by its interaction with Bcl-2 and Bcl-XL, is a distant Bcl-2 family member. Bad bears only the most universally conserved amino acids within BH1 and BH2 domains, and lacks the typical hydrophobic C-terminal signal anchor.
Inmunógeno
synthetic peptide corresponding to amino acids 1-21 of human Bad conjugated to KLH.
Aplicación
Anti-Bad antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL
Acciones bioquímicas o fisiológicas
The protein encoded by this gene forms heterodimers with BCL-xL and BCL-2 and replaces Bax, which in turn inverts the death repressor activity of Bcl-xL and positively regulates cell apoptosis.Bad is phosphorylated on two serine residues embedded in canonical 14-3-3 binding sites in response to IL-3, a survival factor. Phosphorylated Bad does not bind Bcl-XL and is sequestered in the cytosol bound to 14-3-3, a specific phosphoserine-binding protein. The growth factors that promote cell survival activate the threonine kinase Akt, which phosphorylates Bad causing suppression of apoptosis.
Forma física
lyophilized from a 0.2 μm filtered solution of phosphate buffered saline (PBS) and 5% trehalose
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
K Wang et al.
Molecular and cellular biology, 18(10), 6083-6089 (1998-09-19)
The BCL-2 family of proteins is comprised of proapoptotic as well as antiapoptotic members (S. N. Farrow and R. Brown, Curr. Opin. Genet. Dev. 6:45-49, 1996). A prominent death agonist, BAX, forms homodimers and heterodimerizes with multiple antiapoptotic members. Death
Lishuai Feng et al.
International journal of molecular medicine, 42(2), 1074-1085 (2018-05-12)
Mono‑unsaturated free fatty acids (FFAs) can serve as a predictive indicator of vascular restenosis following interventional therapy, particularly in individuals with high‑fat diet‑induced type 2 diabetes. However, the pathogenic mechanism remains to be fully elucidated. In the present study, the
E Yang et al.
Cell, 80(2), 285-291 (1995-01-27)
To extend the mammalian cell death pathway, we screened for further Bcl-2 interacting proteins. Both yeast two-hybrid screening and lambda expression cloning identified a novel interacting protein, Bad, whose homology to Bcl-2 is limited to the BH1 and BH2 domains.
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
Z N Oltvai et al.
Cell, 74(4), 609-619 (1993-08-27)
Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino
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