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A9899

Antazoline hydrochloride

Name: Antazoline hydrochloride
Brand: SIGMA

Sinónimos:

2-(N-Benzylanilinomethyl)-2-imidazoline hydrochloride

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Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₇H₁₉N₃ · HCl

Número CAS:

2508-72-7

Peso molecular:

301.81

NACRES:

NA.77

PubChem Substance ID:

24277763

UNSPSC Code:

12352200

EC Number:

219-719-8

MDL number:

MFCD00058145

Form:

powder

Quality level:

200

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Propiedades

form

powder

Quality Level

200

originator

Novartis

SMILES string

Cl.C1CN=C(CN(Cc2ccccc2)c3ccccc3)N1

InChI

1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H

InChI key

SWKDMSRRIBZZAY-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Descripción

Biochem/physiol Actions

Imidazoline agonist; H₁ histamine receptor antagonist.

Imidazoline agonist; more potent than efaroxan in inducing insulin release from β cells; H₁ histamine receptor antagonist.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Este artículo	D3630	A1210000	N5504
Sigma-Aldrich A9899 Antazoline hydrochloride	Sigma-Aldrich D3630 Diphenhydramine hydrochloride	A1210000 Antazoline hydrochloride	Sigma-Aldrich N5504 Naphazoline hydrochloride
form powder	form powder	form -	form powder
Quality Level 200	Quality Level 200	Quality Level -	Quality Level 100
originator Novartis	originator Johnson & Johnson	originator -	originator Allergan
Gene Information human ... HRH1(3269)	Gene Information human ... HRH1(3269)	Gene Information human ... HRH1(3269)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H315,H319,H335

pcodes

P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis and identification of the primary degradation product in a commercial ophthalmic formulation using NMR, MS, and a stability-indicating HPLC method for antazoline and naphazoline.

S C Ruckmick et al.

Journal of pharmaceutical sciences, 84(4), 502-507 (1995-04-01)

HPLC analysis of an anti-infective ophthalmic solution (Albalon-A), containing the active drugs naphazoline and antazoline, revealed a degradation peak of unknown identity. To elucidate the identity of the degradant, the active drugs were each hydrolyzed by refluxing at high pH

Demand for food and cocaine in Fischer and Lewis rats.

Chesley J Christensen et al.

Behavioral neuroscience, 123(1), 165-171 (2009-01-28)

Fischer and Lewis rat strains often serve as animal vulnerability models for drug abuse and addiction. When these strains respond for drugs of abuse, several measures, including total drug intake, response rate and progressive-ratio breakpoints, have been reported to be

Effects of imidazolines and derivatives on insulin secretion and vascular resistance in perfused rat pancreas.

D Berdeu et al.

European journal of pharmacology, 254(1-2), 119-125 (1994-03-11)

The effects of imidazolines and derivatives were studied on insulin secretion and vascular resistance in the isolated perfused rat pancreas. On insulin secretion, two imidazoline alpha 2-adrenoceptor antagonists, efaroxan (1-100 microM) and RX821002 (10 microM), had a stimulating response; however

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SKU	GTIN
A9899-25G	04061832088778

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