A2661

Acetylcholine chloride

suitable for cell culture

• Sinónimos: ACh
• Fórmula lineal: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• Número de CAS: 60-31-1
• Peso molecular: 181.66
• Beilstein: 3571875
• Número CE: 200-468-8
• Número MDL: MFCD00011698
• Código UNSPSC: 12352209
• eCl@ss: 32190102
• ID de la sustancia en PubChem: 24890686
• NACRES: NA.75

Propiedades

• origen biológico: synthetic
• Análisis: ~99%
• formulario: powder
• técnicas: cell culture | mammalian: suitable
• mp: 146-150 °C (lit.)
• solubilidad: water: 100 mg/mL, clear, colorless
• Condiciones de envío: ambient
• temp. de almacenamiento: room temp
• cadena SMILES: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• Clave InChI: JUGOREOARAHOCO-UHFFFAOYSA-M
• Información sobre el gen: human ... CHRM3(1131)

Descripción

Aplicación

Acetylcholine chloride has been used in the preparation of acetylcholine, that is used as a common vehicle for iontophoresis of acetylcholine (ACh). It has also been used to treat aNS-1 derived neurons for cAMP (cyclic adenosine monophosphate) assay and also used to check their ability to influence G protein-coupled receptors (GPCRs).

Acciones bioquímicas o fisiológicas

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves