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A0384

Arcaine sulfate salt

Sinónimos:

1,4-Diguanidinobutane sulfate salt

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Tamaño de envaseSKUDisponibilidadPrecio
50 mg
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108,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):
C6H16N6 · H2O4S
Número CAS:
14923-17-2
Peso molecular:
270.31
NACRES:
NA.77
PubChem Substance ID:
24277954
UNSPSC Code:
12352200
MDL number:
MFCD00050545
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

108,00 €

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biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

>280 °C

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N

InChI

1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)

InChI key

RWTGFMPOODRXIM-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

Application

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:
  • to evaluate its effects on the acquisition of electrical kindling of the amygdala[1]
  • to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage[2]
  • to study its effects on cell-free translation of synthetic polynucleotide[3]

Biochem/physiol Actions

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine,[3] is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor.[4] Arcaine, an agmatine analog,[2] along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.[1]

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Este artículo
M7033A7127H7278
Arcaine sulfate salt

Sigma-Aldrich

A0384

Arcaine sulfate salt

NG-Methyl-L-arginine acetate salt ≥98% (TLC)

Sigma-Aldrich

M7033

NG-Methyl-L-arginine acetate salt

Agmatine sulfate salt ≥97%, powder

Sigma-Aldrich

A7127

Agmatine sulfate salt

NG-Hydroxy-L-arginine acetate salt

Sigma-Aldrich

H7278

NG-Hydroxy-L-arginine acetate salt

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥97%

assay

≥98% (TLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

H2O: 50 mg/mL, ethanol: insoluble

solubility

acetic acid: 10 mg/mL, clear, colorless to faintly yellow

mp

>280 °C

mp

-

mp

234-238 °C (lit.)

mp

204 °C

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
SLCL4063
SLCF8524
SLBT4233
SLBR2066V
SLBJ9045V

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Nádia Aléssio Velloso Bellé et al.
Brain research, 1008(2), 245-251 (2004-05-18)
Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe+2) stimulate production of free radicals and lipid peroxidation. In the present study, we investigated the
J F Atkins et al.
The Journal of biological chemistry, 250(14), 5688-5695 (1975-07-25)
Addition of the polyamines spermidine, spermine, or putrescine to a fractionated mammalian cell-free protein-synthesis system programmed by a variety of mRNAs results in a 3- to 5-fold stimulation of amino acid incorporation over that found in the absence of added
D L Yourick et al.
European journal of pharmacology, 371(2-3), 147-152 (1999-06-05)
The NMDA receptor complex is thought to be altered in kindling, an animal model for complex partial epilepsy. This receptor complex has several modulatory sites including those for glutamate, glycine and polyamines with activation resulting in altered cation channel opening.
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SKUGTIN
A0384-50MG04061832088501

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