19953

Ricobendazole

≥98% (HPLC)

• Sinónimos: Albendazole oxide, Albendazole sulfoxide, Methyl [5-(propane-1-sulfinyl)-1H-benzoimidazol-2-yl]-carbamate
• Fórmula empírica (notación de Hill): C₁₂H₁₅N₃O₃S
• Número CAS: 54029-12-8
• Peso molecular: 281.33
• PubChem Substance ID: 329751959
• UNSPSC Code: 51101500
• Beilstein/REAXYS Number: 677664
• MDL number: MFCD00797922

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: colorless to white
• antibiotic activity spectrum: neoplastics, parasites
• mode of action: DNA synthesis | interferes, enzyme | interferes, protein synthesis | interferes
• SMILES string: CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1
• InChI: 1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
• InChI key: VXTGHWHFYNYFFV-UHFFFAOYSA-N

Descripción

General description

Chemical structure: benzimidazole

Application

Ricobendazole is a methylcarbamate benzimidazole with a broad-spectrum anthelmintic activity. Ricobendazole is a key metabolite of albendazole [1]. It has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting the cell cycle at the G₂/M phase.[2]

Biochem/physiol Actions

Ricobendazole is a key metabolite of albendazole and acts as an anthelmintic. It has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting cell cycle at the G₂/M phase.

Packaging

25G

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Información de seguridad

• pictograms: GHS08,GHS07,GHS09
• signalword: Warning
• hcodes: H317,H361d,H373,H410
• pcodes: P201 - P273 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1 - STOT RE 2 Oral
• target_organs: Adrenal gland,spleen,male reproductive organs,Blood
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves