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32103

Posaconazole

VETRANAL®, analytical standard

Sinónimos:

4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

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Tamaño de envaseSKUDisponibilidadPrecio
25 mg
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110,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):
C37H42F2N8O4
Número CAS:
171228-49-2
Peso molecular:
700.78
NACRES:
NA.24
PubChem Substance ID:
329753992
UNSPSC Code:
41116107
MDL number:
MFCD00941162

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grade

analytical standard

Quality Segment

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

SMILES string

CC[C@@H]([C@H](C)O)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OC[C@@H]5CO[C@@](C5)(Cn6cncn6)c7ccc(F)cc7F)cc4

InChI

1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1

InChI key

RAGOYPUPXAKGKH-XAKZXMRKSA-N

General description

Posaconazole is an azole antifungal drug used mostly against zygomycetes.

Application

Posaconazole may have been used as reference standard in HPLC analysis for quantification of posaconazole from human plasma.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Este artículo
32355SML228732483
Posaconazole VETRANAL®, analytical standard

Supelco

32103

Posaconazole

Terconazole VETRANAL®, analytical standard

Supelco

32355

Terconazole

Posaconazole ≥98% (HPLC)

Sigma-Aldrich

SML2287

Posaconazole

Voriconazole VETRANAL®, analytical standard

Supelco

32483

Voriconazole

application(s)

clinical testing

application(s)

forensics and toxicology
veterinary

application(s)

-

application(s)

forensics and toxicology
pharmaceutical (small molecule)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

grade

analytical standard

grade

analytical standard

grade

-

grade

analytical standard

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

limited shelf life, expiry date on the label

product line

VETRANAL®

product line

VETRANAL®

product line

-

product line

VETRANAL®

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
BCCN5887
BCCK0662
BCCH9785
BCCC8920
BCCB7317

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Visite la Librería de documentos

Sophida Boonsathorn et al.
Clinical pharmacokinetics, 58(1), 53-61 (2018-04-22)
The objectives of this study were to investigate the population pharmacokinetics of posaconazole in immunocompromised children, evaluate the influence of patient characteristics on posaconazole exposure and perform simulations to recommend optimal starting doses. Posaconazole plasma concentrations from paediatric patients undergoing
Michael N Trinh et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), 89-94 (2016-12-21)
Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal cholesterol export is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug [Xu et
Olga Rivero-Menendez et al.
The Journal of antimicrobial chemotherapy, 74(6), 1586-1590 (2019-03-21)
To investigate the in vitro activity of olorofim (F901318), a novel broad-spectrum antifungal agent, against 150 strains belonging to 16 different cryptic species of Aspergillus by EUCAST and CLSI methodologies. Olorofim, amphotericin B, micafungin, posaconazole and voriconazole were tested against
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Número de artículo de comercio global

SKUGTIN
32103-25MG04061835560240

Preguntas

  1. Hello, is this product suitable to be used for minimum inhibitory concentration testing?

    1 respuesta

    1. This product is intended for use as an analytical standard in chemical assays, such as chromatography, spectroscopy, and mass spectrometry. The material is not tested for biological activity. Note that product SML2287 is also available and intended for general laboratory use. Please see the link below to review additional details regarding this product:
      https://www.sigmaaldrich.com/product/sigma/sml2287

      Please see the following link to review a publication focusing on MIC (Minimum Inhibitory Concentration) in several organisms:
      https://pmc.ncbi.nlm.nih.gov/articles/PMC3043502/

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