Kinesin-like protein KIF3 (KIF3A) is a member of the heteromeric family of kinesins and plays an important role in primary cilia formation. KIF3A functions as a microtubule-based anterograde translocator for membranous organelles and forms a heterotrimeric KIF3 complex with KIF3B or KIF3C and an associated protein, KAP3. Mutations in in KIF3A have been associated with cranial base growth retardation and dysmorphogenesis.
~80 kDa observed
Immunogen
KLH-conjugated linear peptide corresponding to human KIF3A.
Application
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected KIF3A in A431, HeLa, and NIH/3T3 cells.
Research Category Apoptosis & Cancer
Research Sub Category Apoptosis - Additional
This Anti-KIF3A Antibody is validated for use in ICC for the detection of KIF3A.
Biochem/physiol Actions
Other homologies: Mouse, Rat, Chicken, Zebrafish, and Frog (92% sequence homology).
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control SH-SY5Y cell lysate
Evaluated by Western Blot in SH-SY5Y cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected KIF3A in 10 µg of SH-SY5Y cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clase de almacenamiento
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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