The maximum temperature that this resin can withstand has not been determined. Upon reviewing available literature, one citation reports usage of Wang resin at 40–50°C. Please see the link below to review this publication:
https://www.sciencedirect.com/topics/chemistry/wang-resin
8.55117
Hydroxylamine Wang resin
Novabiochem®
Sinónimos:
Amino-oxy Wang resin
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 5 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 176,00 € | |
| 25 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 698,00 € | |
| 100 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 2630,00 € |
Acerca de este artículo
NACRES:
NA.22
UNSPSC Code:
12352116
176,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleQuality Segment
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-8°C
General description
An excellent support for the preparation of peptide hydroxamic acids [1] by Fmoc SPPS. Acylation of the resin has been carried out using TBTU/DIPEA activation [1]. Alkylation of the resin-bound nitrogen has been effected using TMOF/DCE/AcOH for imine formation, followed by reduction with BH3-pyridine [2], by base-mediated alkylation of the N-Boc-protected hydroxylamine, followed by Boc removal with 20% TFA in DCM [3], or by Michael-addition [4]. Cleavage of hydroxamates from the resin has been effected with TFA/DCM/water (70:28:2) [1] or TFA/DCM (1:1) [2]. Hydroxylamine Wang resin has also been utilized to prepare tertiary amines by base-mediated elimination of the quaternized polymer-bound hydroxylamine [3, 5].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
[2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
[3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
[4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
[5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
[2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
[3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
[4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
[5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of nitrogen): 1.5 - 2.5 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Appearance of substance (visual): beads
Loading (determined by elemental analysis of nitrogen): 1.5 - 2.5 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Other Notes
Replaces: 01-64-0454
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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Este artículo | |||
|---|---|---|---|
| reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis |
| product line Novabiochem® | product line Novabiochem® | product line - | product line Novabiochem® |
| Quality Level 200 | Quality Level 400 | Quality Level 100 | Quality Level 200 |
| application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis |
| storage temp. 2-8°C | storage temp. 2-30°C | storage temp. - | storage temp. 2-30°C |
| form beads | form beads | form solid | form beads |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 8551170005 | 04027269114619 |
| 8551170025 | 04027269114626 |
| 8551170100 | 04027269114633 |
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What is the maximum temperature that this resin can withstand?
1 respuesta-
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Does this Wang resin have a Fmoc group on it? Do I need to remove it when I first use it? Thanks so much!
1 respuesta-
This resin doesn't contain a Fmoc group but it can be added. Please refer to the following article, https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/peptide-synthesis/peptide-resin-loading.
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