5.33756

Ac-CoA Synthase Inhibitor

• Sinónimos: Ac-CoA Synthase Inhibitor, 1-(2,3-di(Thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea, N-(2,3-di-2-Thienyl-6-quinoxalinyl)-Nʹ-(2-methoxyethyl)urea, Acyl-CoA Synthetase 2 short-chain Inhibitor; short-chain Acetyl-CoA Synthetase 2 Inhibitor, ACSS2 Inhibitor
• Fórmula empírica (notación de Hill): C₂₀H₁₈N₄O₂S₂
• Número de CAS: 508186-14-9
• Peso molecular: 410.51
• Código UNSPSC: 51111800
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• Nivel de calidad: 100
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: yellow
• solubilidad: DMSO: 50 mg/mL
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C20H18N4O2S2/c1-26-9-8-21-20(25)22-13-6-7-14-15(12-13)24-19(17-5-3-11-28-17)18(23-14)16-4-2-10-27-16/h2-7,10-12H,8-9H2,1H3,(H2,21,22,25)
• Clave InChI: CTPVNWVUAGMHEJ-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC₅₀ ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of ¹⁴C tracer carbons from acetate into lipids (IC₅₀ = 6.8 µM) and for histone acetylation (IC₅₀ = 5.5 µM) in HepG2 cells.

A cell-permeable quinoxaline based compound that acts as a potent, reversible inhibitor of acetyl CoA synthetase (ACSS2; IC₅₀ ~ 600 nM in a luciferase based assay). Exhibits selectivity over ACSF2 and ACSL5 acyl-CoA synthetases. Efficiently blocks the uptake of ¹⁴C tracer carbons from acetate into lipids (IC₅₀ = 6.8 µM) and for histone acetylation (IC₅₀ = 5.5 µM) in HepG2 cells.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Acciones bioquímicas o fisiológicas

Primary Target
ACSS2

Reversible: yes

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Comerford, S.A., et al. 2014. Cell.159, 1591.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable