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Documentos

516705

Sigma-Aldrich

o-Phenanthroline

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells.

Sinónimos:

o-Phenanthroline, 1,10-Phenanthroline Monohydrate

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About This Item

Fórmula empírica (notación de Hill):
C12H8N2 · xH2O
Número de CAS:
5144-89-8
Peso molecular:
180.21 (anhydrous basis)
Número MDL:
MFCD00149973
Código UNSPSC:
51111800
NACRES:
NA.77

Nivel de calidad

100

Análisis

≥99% (titration)

formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

white to cream

solubilidad

DMSO: 100 mg/mL
ethanol: 25 mg/mL
water: 3 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

10-30°C

InChI

1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2

Clave InChI

PPQJCISYYXZCAE-UHFFFAOYSA-N

Descripción general

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general matrix metalloproteinase inhibitor. Forms a red chelate with Fe2+ that absorbs maximally at 510 nm. Can be used as a photometric reagent for iron.
A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a metalloprotease inhibitor. Inhibits glioma invasion in vitro.

Acciones bioquímicas o fisiológicas

Cell permeable: no
Primary Target
Metalloprotease inhibitor
Product does not compete with ATP.
Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Toxic (F)

Otras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Stix, B., et al. 2001. Am. J. Pathol.159, 561.
Bolzan, A.D., et al. 2000. Mutat. Res.447, 221.
Wang, Y., et al. 1999. J. Biol. Chem.274, 33043.
Harayama, T., et al. 1999. Jpn. J. Can. Res.90, 942.
Krane, S.M., et al. 1996. J. Biol. Chem.271, 28509.
Uhm, J.H., et al. 1996. Clin. Exp. Metastasis14, 421.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Skull and crossbonesEnvironment
GHS06,GHS09

Palabra de señalización

Danger

Frases de peligro

H301,H410

Clasificaciones de peligro

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Joka Pipercevic et al.
Nature communications, 14(1), 2645-2645 (2023-05-09)
Many proteins involved in eukaryotic phosphate homeostasis are regulated by SPX domains. In yeast, the vacuolar transporter chaperone (VTC) complex contains two such domains, but mechanistic details of its regulation are not well understood. Here, we show at the atomic
Nuria Gutierrez-Prat et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(29) (2021-07-18)
Cell survival in response to stress is determined by the coordination of various signaling pathways. The kinase p38α is activated by many stresses, but the intensity and duration of the signal depends on the stimuli. How different p38α-activation dynamics may
Paul Y Bi et al.
Communications biology, 7(1), 391-391 (2024-03-31)
Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged DELE1 showed that these stresses induced the cleavage of DELE1 to DELE1-S

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