420107-M

Jasplakinolide, Jaspis johnstoni

A cell-permeable F-actin probe.

• Sinónimos: Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem
• Fórmula empírica (notación de Hill): C₃₆H₄₅BrN₄O₆
• Número de CAS: 102396-24-7
• Peso molecular: 709.67
• Número MDL: MFCD00873735
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥95% (HPLC)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: off-white
• solubilidad: DMSO: 10 mg/mL
• temp. de almacenamiento: −20°C
• InChI: 1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22+,23-,24-,30+,31+/m0/s1
• Clave InChI: GQWYWHOHRVVHAP-HZIRKPFGSA-N

Descripción

Descripción general

A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca²⁺ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (K_d = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.

Acciones bioquímicas o fisiológicas

Kd = 15 nM for actin binding

Primary Target
Inducer of actin polymerization and stabilization in vitro

Advertencia

Toxicity: Harmful (C)

Otras notas

Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable