324732
ErbB2 Inhibitor II
The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Sinónimos:
ErbB2 Inhibitor II, 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
Iniciar sesión para ver los precios por organización y contrato.
Acerca de este artículo
Fórmula empírica (notación de Hill):
C15H10N4O
Número CAS:
Peso molecular:
262.27
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cheng, Z. Y., et al. 2007. Bioorg. Med. Chem.15, 1533.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
1 of 1
Este artículo | |||
|---|---|---|---|
| form solid | form solid | form solid | form solid |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (GC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 50 mg/mL | solubility DMSO: 10 mg/mL, THF: soluble, acetone: soluble | solubility DMSO: 50 mg/mL | solubility DMSO: 5 mg/mL |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.