211875

Captopril

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC₅₀ = 11 µM).

• Sinónimos: Captopril, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
• Fórmula empírica (notación de Hill): C₉H₁₅NO₃S
• Número de CAS: 62571-86-2
• Peso molecular: 217.29
• Número MDL: MFCD00168073
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (titration)
• formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: white to off-white
• solubilidad: water: 1 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• Clave InChI: FAKRSMQSSFJEIM-RQJHMYQMSA-N

Descripción

Descripción general

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC₅₀ = ~ 320 nM).

An antihypertensive agent. Reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
ACE

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Otras notas

Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H341,H360F
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Muta. 2 - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable